Molybdenum disulfide (MoS) field-effect transistor (FET)-based biosensors have attracted significant attention as promising candidates for highly sensitive, label-free biomolecule detection devices. In this paper, toward practical applications of biosensors, we demonstrate reliable and quantitative detection of a prostate cancer biomarker using the MoS FET biosensor in a nonaqueous environment by reducing nonspecific molecular binding events and realizing uniform chemisorption of anti-PSA onto the MoS surface. A systematic and statistical study on the capability of the proposed device is presented, and the biological binding events are directly confirmed and characterized through intensive structural and electrical analysis. Our proposed biosensor can reliably detect various PSA concentrations with a limit of 100 fg/mL. Moreover, rigorous theoretical simulations provide a comprehensive understanding of the operating mechanism of the MoS FET biosensors, and further suggests the enhancement of the sensitivity through engineering device design parameters.
Renal VII is typically lower in DN than in controls and moderately correlated with SCC, which reflects renal function in DN, but does not offer a significant advantage over arterial resistance index.
Flexible sensors connected to cell phones are a promising technology that can aid in continuously monitoring signals in our daily lives, such as an individual’s health status and information from buildings, farms, and industry. Among such signals, real-time humidity monitoring is crucial to a comfortable life, as human bodies, plants, and industrial environments require appropriate humidity to be maintained. We propose a hydrophilic polytetrafluoroethylene (H-PTFE)-based flexible humidity sensor integrated with readout circuitry, wireless communication, and a mobile battery. To enhance its sensitivity, linearity, and reliability, treatment with sodium hydroxide implements additional hydroxyl (OH) groups, which further enhance the sensitivity, create a strong linearity with respect to variations in relative humidity, and produce a relatively free hysteresis. Furthermore, to create robust mechanical stability, cyclic upward bending was performed for up to 3000 cycles. The overall electrical and mechanical results demonstrate that the flexible real-time H-PTFE humidity sensor system is suitable for applications such as wearable smart devices.
The
detection of circulating protein (CP) is very important for
the diagnosis and therapeutics of cancer. Conventional techniques
based on a specific antibody–antigen interaction are still
lacking because of a shortage of cost effectiveness, complicated sandwich
structure and tagging process, and inconsistent detection of CP due
to the inherent instability of antibodies. Herein, we demonstrate
a hybrid device consisting of two-dimensional (2D) nanoscale molybdenum
disulfide (MoS2) field-effect transistor (FET) with an
amyloid-β1–42 (Aβ1–42) functionalized surface, which amplifies electric signals of the
FET in order to detect matrix metalloproteinase-9 (MMP-9), which is
a certain type of CP that degrades Aβ1–42.
With the hybrid device, we detected the concentrations of MMP-9 in
the range from 1 pM to 10 nM. Moreover, using tapping-mode atomic
force microscopy and Kelvin probe force microscopy, we verified that
the signal amplification corresponding to the MMP-9 concentrations
was caused by the reduced length and the decreased surface potential
of degraded Aβ1–42 due to MMP-9. The hybrid
device studied in this paper can be very useful for monitoring MMP-9
activity, as well as serving as a sensing platform for the electrical
signal amplification of 2D MoS2 FET-biosensors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.