At 6 weeks of age, 194 cockerels (Warren) were randomly assigned to either a control group or linear alkylbenzen sulphonate (LAS) feeding groups. All the birds had free access to feed and water, though the birds in LAS feeding groups were supplied with water containing LAS at the concentrations of 10 and 100ppm. At 16 weeks of age, LAS concentration in the drinking water of LAS 100ppm group was raised to 1500ppm. Body weight, feed consumption and water intake per each group were determined weekly. Sixteen birds per group were killed at 10, 15, 21 and 28 weeks of age and their organs were dissected and weighed. Enzyme activities in the serum and the liver from these birds were determined. The semen was collected from the control and LAS treated birds when they attained to 26 weeks of age to calculate the number of spermatozoon.The addition of LAS at the concentrations of 10-100ppm did not greatly affect body weight, feed intake, organ weights and sperm concentration in the cockerels, but increased serum transaminase (GOT) activity (10-15 weeks of age) and total cholesterol level (15 weeks of age), and decreased serum triglyceride level (10 weeks of age). When LAS concentration was raised to 1500ppm, it caused significant decreases in water intake, body weight, testes weight, comb weight and sperm concentration in seminal fluid. In response to this high LAS concentration the birds showed significant decreases in activities of serum transaminase (GOT), alkaline phosphatase, lactic dehydrogenase and of liver mitochondrial transaminase (GPT), and a significant increase in serum triglyceride concentration. Based on these results, it seemed likely to conclude that the intake of LAS at a dose of about 80mg per kg of body weight daily would seriously inhibit growth and sexual maturation in the cockerel.(Japan. Poult. Sci., 18, 51-59, 1981)
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