Objective The aim of this study was to determine differences in GCF and serum levels of fractalkine/CX3CL1 and its receptor/ CX3CR1 between the patients with stage III/grade B periodontitis and periodontally healthy subjects. Background Fractalkine (CX3CL1), the only member of CX3C chemokine family, is involved in the pathogenesis of several systemic inflammatory diseases’ disorders including rheumatoid arthritis, cardiovascular diseases, tonsillitis, and diabetes mellitus. It has critical functions in inflammatory cell migration, adhesion, and proliferation. Methods 20 stage III/grade B periodontitis (P) and 20 healthy individuals (control; C) were included in this clinical study (all never smokers and systemically healthy). Clinical periodontal parameters were measured. Serum and GCF levels of CX3CL1, CX3CR1, and IL‐1β were quantified by enzyme‐linked immunosorbent assay and reported as total amounts and concentration. Results The GCF concentrations and also total amount of CX3CL1, CX3CR1, and IL‐1β were statistically significantly higher in the patients with periodontitis compared with control group (P < 0.05). CX3CL1, CX3CR1, and IL‐1β levels in the GCF were significantly and positively correlated with all the clinical periodontal parameters (PI, PPD, BOP, and CAL; P < 0.01, P < 0.05). There was a significant correlation between IL‐1β, CX3CL1, and CX3CR1 concentrations in the GCF (respectively; r = 0.838 and r = 0.874, P < 0.01). Conclusion Fractalkine and its receptor may play role in mechanisms through the regulation of inflammation or on the pathogenesis of periodontal disease.
Objectives: It has been stated that Sirtuin-6 (SIRT6) play a important role in regulation of inflammation, energy metabolism, homeostasis and apoptosis, and SIRT6 may be assosiciated with many diseases. The aim of this study was to evaluate saliva and serum SIRT6, Lipoxin A4 (LXA4) and Caspase-8 (CASP8) levels in correlation with periodontal clinical status in patients with periodontitis and healthy subjects. Materials and Methods: 20 patients with Stage III Grade B periodontitis (P) and 20 periodontally healthy individuals (control;C) were included in this study. Clinical periodontal parameters were measured. Saliva and serum levels of SIRT6, LXA4 and CASP8 were analyzed by enzyme-linked immunosorbent assay.Results: Serum SIRT6 and saliva LXA4 levels were significantly lower in the periodontitis group than in the control group (respectively; p=0.010, p= p:0.001). There was no statistically significant difference between the periodontitis and control groups for saliva SIRT6, serum LXA4, serum and saliva CASP8 levels (p>0.05). Significant negative correlations were found between all periodontal clinical parameters (PI, BOP, PPD, CAL) and saliva LXA4 level (p<0.05), and between PPD, CAL, and serum SIRT6 level (respectively; r=-0.465 and r=-0.473, p<0.05). Conclusions: This study demonstrated that significantly lower levels of serum SIRT6 and saliva LXA4 in periodontitis patients and their correlation with periodontal status. Detection of SIRT6 and saliva LXA4 might have a potential role for predicting periodontal status in the future with more precise sampling protocols and with better specifity in testing methods. Clinical Relevance: Serum SIRT6 and saliva LXA4 might be promising biomarkers for monitoring the susceptibility to periodontitis and predicting periodontal status.
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