Objective To investigate fibronectin levels in urine of surgery. The other two patients showed elevated levels of fibronectin for > 4 weeks. samples from patients with noninvasive transitional cell carcinoma (TCC) of the bladder immediately andConclusions These results show that urinary fibronectin concentration is significantly increased in most for 4 weeks after transurethral resection of bladder tumour (TURBT), to determine whether soluble fibpatients after TURBT and this should be considered in patients who receive BCG therapy. Treatment within ronectin within the bladder, which blocks the attachment of bacillus Calmette-Guérin (BCG), might lower the first 2 weeks after TURBT may be associated with a high failure rate, as urinary fibronectin levels were the eBcacy of BCG therapy over this period. Patients and methods Urinary fibronectin was measured increased significantly in about three-quarters of these patients during that period. Indeed, the persistent using an enzyme-linked immunosorbent assay in 25 patients with superficial bladder TCC who underwent elevation of fibronectin, occurring in two of the present patients, may be responsible for some of the failures TURBT for complete resection. Eight samples were collected for each patient, one before and seven during of BCG therapy when it is administered 2-5 weeks after surgery. the 4 weeks after TURBT. Results High levels of urinary fibronectin were detected Keywords Bladder tumour, TCC, fibronectin, BCG, therapy, eBcacy, recurrence in 18 patients (72%) after TURBT. In 16 patients the fibronectin level returned to normal within 2 weeks disruption. Fibronectin is a glycoprotein with a molecular
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