We report a case of IgG multiple myeloma with selective complete Clq deficiency. The patient was a 75-year-old Japanese womanwho exhibited urticaria on the arm and an absence of serum hemolytic complement activity (CH50). Further studies revealed no vasculitis in the urticaria! lesion but showed selective complete deficiency of Clq without low molecular weight Clq precipitin. Addition of highly purified Clq restored the CH50 level of the patient's serum to normal. It is suggested that this abnormality was a primary Clq deficiency. Wediscussed a relationship between the Clq deficiency and myeloma and reviewed the literature.
Abstract. Sixty-five small colonic lesions, less than 20 mm in diameter, were studied by scanning electron microscopy (SEM). They appeared protruded or depressed colonoscopically and were excised from 35 patients by strip biopsy. As a result, crypt orifices on the mucosal surfaces of the depressed lesions were less than 10 am in diameter. In the depressed lesions and in the carcinoma, mucosal epithelial cells and goblet cells were displaced, and partial mucosal destruction existed in the carcinoma.
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