Introduction: Migraine is one of the most common neurological diseases. The pathophysiology of migraine has not yet been fully elucidated. There is increasing evidence supporting the relationship between oxidative stress and migraine.Method: This is a retrospective, cross-sectional and observational study. The patients were divided into two groups, episodic migraine and chronic migraine. Episodic migraine patients were divided into two subgroups, migraine with aura and migraine without aura. Serum Albumin, total bilirubin, uric acid levels, and migraine clinical findings were obtained from medical records.Results: A total of 181 participants, 88 patients and 93 controls, were included in the study. Serum albumin levels were lower in the patient group than in the control group, they did not reach statistical significance (p=0.082). There was no significant difference between the patient and control groups for total bilirubin levels (p=0.785). Serum uric acid levels in the patient group were found to be significantly lower than in the control group (p<0.001). Measured levels were similar in chronic and episodic migraine groups, and migraine with aura and migraine without aura subgroups. Conclusion:We thought this oxidative stress marker may be associated with the presence of migraine, but this is not significant for migraine subtypes and migraine progression.
Subunit (<i>CHRNA7</i>) gene, and expression of gene-targeting miRNAs (hsa-miR-548e-5p and hsa-miR-3158-5p) in migraineurs (n = 102; with aura, n = 43; without aura, n = 59) and non-migraines (n =120) aged 15-60 years, comparative, case-control study was conducted. Genetic markers were compared with biochemical parameters (BMI, WBC, Urea, GFR, ESR, CRP, HBG). All analyzes were performed by quantitative Real-Time PCR (q-PCR) and fold change was calculated with the 2-<sup>ΔΔCT</sup> method. The diagnostic power of the <i>CHRNA7</i> gene, CNV, and miRNAs were analyzed with the receiver operating curve (ROC). <i>CHRNA7</i> gene and hsa-miR-3158-5p are down-regulated in migraineurs and the gene is controlled by this miRNA via CNVs (p<0.05). Both deletion and duplication were detected in patients with migraine for CVN numbers (P = 0.05). The number of CNV deletions was higher than duplications. When CHRNA7-CNV-hsa-miR-3158-5p was modeled together in the ROC analysis, the area under the curve (AUC) was 0.805, and the diagnostic power was "good". In migraineurs, the <i>CHRNA7</i> gene can be controlled by hsa-miR-3158-5p via CNVs to modulate the mechanism of pain. These three genetic markers have diagnostic potential and may be used in antimigraine treatments.
Smartphones have become essential to life in Western society. This situation reached its peak, especially during the pandemic period. The possibility that smartphone use has negative impact on brain activity has attracted increasing interest among researchers. Medical faculty students were contacted via e-mail and invited to participate in the study. Participants completed the Smartphone Addiction Scale (SAS), the Mental Fatigue Scale (MFS), and the Cognitive Flexibility Inventory (CFI). The total SAS scores of participants with mental fatigue were significantly higher than those of participants without mental fatigue (p < 0.001). In the smartphone addiction tendency group, the total MFS scores were significantly higher, and the total CFI scores were significantly lower than the scores of the control group (p < 0.001 for both). In the logistic regression analysis, the total SAS score was associated with the development of mental fatigue (B coefficient, 0.031, p < 0.001). This study identified potential relationships between smartphone addiction, mental fatigue, and cognitive flexibility. We suggest that smartphone overuse may be an independent risk factor for the development of mental fatigue.
Objective: Migraine is a common neurological syndrome that affects 15% of the population. The pathogenesis of migraines is not fully understood. In the nervous system; magnesium plays critical roles such as nerve conduction, neuromuscular coordination and protection against excitotoxicity. Method: In this retrospective study, patients were diagnosed with migraine according to the International Classification of Headache Disorders-3 beta criteria were included. Patients were divided into three groups as migraine with aura, migraine without aura and chronic migraine. Results: A total of 168 participant, 71 patients and 97 controls, were included in the study. Serum Mg values were measured as 1.98 mg/dl in the patient group and 2.04 mg/dl in the control group and were found to be significantly lower in the patient group (p=0.021). No significant difference was found in terms of mean serum Mg values in migraine subgroups. Conclusion: We found that serum Mg levels are low in migraine patients and we think that this vital cation may be one of the factors playing a role in the pathogenesis of migraine. Evaluation of serum Mg level in migraine patients may help in predicting migraine attacks and symptoms, as well as in appropriate therapeutic planning for patients.
Amaç: Beyin damar hastalıklarının nadir görülen grubunu oluşturan subaraknoid kanama, mortalite ve morbiditesi yüksek bir hastalıktır. Tedavi ve takip süreci oldukça zordur. Tedavisi multidisipliner yaklaşım gerektirir. Klinik gidişata etki eden parametreler bu hastalıkta hep bir merak konusu olmuştur. Bu yazıda bizim amacımız; Vitamin-D seviyelerinin nörolojik yoğun bakım ünitesinde takip edilen subaraknoid kana-malı hastaların klinik gidişatları üzerine etkisini araştırmak oldu.Materyal ve metod: Ekim 2019-Ekim 2021 tarihleri arasında subaraknoid kanama ile hastanemiz acil servisine başvuran 45 hasta retrospektif olarak taranmıştır.Bu hastaların klinik, labaratuvar ve detaylı anjio raporları hasta dosyalarından elde edilmiştir.Bulgular: Olgular D vitamini 20ng/ml den düşük olanlar ve bu değerden daha yüksek olanlar şeklinde iki gruba ayrıldı. Tüm olguların 23’inde (% 51) Vit-D düzeyleri 20 ng/ml’den düşük saptanmış olup, 22’sinde ise (%49) Vit-D 20ng/ml’den daha yüksek olarak saptandı .Cinsiyet, Vasospazm, Hidrosefali, Epiletik nöbet, yoğun bakım yatış süresi, mekanik ventilasyon süresi, Glaskow koma skalası (GKS) ve exitus oranları bu iki grup arasında karşılaştırıldı birçoğunda istatistiksel olarak anlamlılık saptanmadı.Sonuç: Subaraknoid kanama tanılı hastalarımızda Vit-D eksikliği ve/veya yetersizliği yüksek oranda mev-cuttu. Daha ileri çalışmalara gerek duymakla birlikte Vit-D seviyesi ile subaraknoid kanamalı hastaların prognozu arasında ilişki bulunamamıştır.Anahtar Kelimeler: Subaraknoid kanama, Nörolojik yoğun bakım, Vit-D
Introduction White matter hyperintensities (WMHs) are frequently detected on magnetic resonance imaging (MRI) with age. Although the etiology of WMH has not been fully explained, it was reported to be associated with internal carotid artery (ICA) stenosis as well as small vessel diseases. The number and volume of these lesions might increase in cases of internal carotid artery (ICA) stenosis. The present study aimed to calculate the localization and volumes of white matter lesions in the VolBrain Program and investigate the relationship between age and sex in patients with symptomatic and asymptomatic internal carotid artery stenosis. Methods MRI scans of patients with carotid stenosis with T1-weighted and fluid-attenuated inversion recovery (FLAIR) sequences were performed retrospectively for the present study, which had a retrospective design. The patients were divided into two groups (<70% and ≥70%) because endovascular intervention was considered in patients with asymptomatic stenosis over 70%. Digital subtraction angiography was used to detect carotid artery stenosis. They were also divided into four groups. According to laterality and degree of stenosis, ICA stenosis was separated as those with <70% stenosis on both sides (group 1), right side ICA <70%, left side ≥70% stenosis (group 2), right side ICA ≥70%, left side <70% stenosis (group 3), and ≥70% stenosis on both sides (group 4). A total of 102 patient images were selected that met the inclusion criteria. The measurements of white matter lesion volumes were made using the LesionBrain application in the VolBrain Program. Results The MRI of 82 patients (mean age: 65.55 ± 9.28 years), 28 females and 54 males, were used in the present study. According to LesionBrain Analysis, the total WMH volume was seen in the first and third groups at most. When analyzed in regional terms, stenosis was mostly detected in the first and third groups in the periventricular region. WMH volume was less in all areas in group 4. When examined according to the number of lesions, the most lesions were detected in the third group in the juxtacortical region. When the difference between the groups was examined, a significant difference was detected only in the volume change in the deep white region (p=0.011). No significant differences were found between WMH volumes and age and gender (p>0.05). Conclusion Stenosis of the external internal carotid artery might cause hypoperfusion and silent embolization in the brain. As a result, as well as pathological conditions in cortical areas, ischemic areas in the white matter might also cause cognitive disorders.
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