Decreased Serum Uric Acid Level as an Indicator of Altered Oxidative Balance in Patients With Migraine

Abstract

Introduction: Migraine is one of the most common neurological diseases. The pathophysiology of migraine has not yet been fully elucidated. There is increasing evidence supporting the relationship between oxidative stress and migraine.Method: This is a retrospective, cross-sectional and observational study. The patients were divided into two groups, episodic migraine and chronic migraine. Episodic migraine patients were divided into two subgroups, migraine with aura and migraine without aura. Serum Albumin, total bilirubin, uric acid levels, and migraine clinical findings were obtained from medical records.Results: A total of 181 participants, 88 patients and 93 controls, were included in the study. Serum albumin levels were lower in the patient group than in the control group, they did not reach statistical significance (p=0.082). There was no significant difference between the patient and control groups for total bilirubin levels (p=0.785). Serum uric acid levels in the patient group were found to be significantly lower than in the control group (p<0.001). Measured levels were similar in chronic and episodic migraine groups, and migraine with aura and migraine without aura subgroups. Conclusion:We thought this oxidative stress marker may be associated with the presence of migraine, but this is not significant for migraine subtypes and migraine progression.

Association between oxidative stress and chronic orofacial pain and potential druggable targets: Evidence from a Mendelian randomization study

“…Yasin et al. found that UA level decreased in migraine patients, and UA was an effective extracellular free radical scavenger 46 . This evidence suggests UA is more likely to play a protective role as an antioxidant agent in the pathogenesis of oxidative stress and orofacial pain.…”

“…45 Yasin et al found that UA level decreased in migraine patients, and UA was an effective extracellular free radical scavenger. 46 This evidence suggests UA is more likely to play a protective role as an antioxidant agent in the pathogenesis of oxidative stress and orofacial pain. Recently studies mainly focus on evaluating the effective index of medicine in the treatment of chronic pain through GST levels.…”

Gout and Migraines: Exploring the Complex Link in a 16-Year Longitudinal Study of the Korean Population

“…In light of the well-understood etiopathogenesis of gout, with hyperuricemia as a primary intermediary step, attention has been drawn to the repeated observations of a potential link between serum uric acid levels and migraine occurrence [ 23 , 24 , 25 , 26 ]. For instance, a cross-sectional cohort study revealed an exponential relationship between serum urate levels and migraine occurrence when serum urate exceeded 7.8 mg/dL [ 24 ].…”

“…These findings suggest elucidation of the possible relationship between gout and migraine. However, the studies referenced are indeed cross-sectional in nature [ 23 , 24 , 25 , 26 ], and they do not encompass follow-up data [ 27 ]. This underscores the need for further research employing national population cohort data, which includes meticulous demographic matching and long-term follow-up, to replicate and substantiate the potential link observed in these studies.…”