This mini-review discusses some of the recent work on Novel Process Windows by the group of Micro Flow Chemistry and Process Technology at the Eindhoven University of Technology, and their associates. Novel Process Windows consist of unconventional approaches to boost chemical production, often requiring harsh reaction conditions at short to very short time-scales. These approaches are divided into six routes: the use of high temperatures, high pressures, and high concentrations (or solvent-free), new chemical transformations, explosive conditions and process simplification and integration. Microstructured reactors, due to their inherent safety, short timescales and the high degree of process control, are the means that make such extreme chemistry possible.
The methoxycarbonylation of cyclohexene with carbon dioxide over a ruthenium catalyst was realized in a micro flow system under supercritical conditions.
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