A View Through Novel Process Windows

Stouten, SC Stefan; Noël, Timothy; Wang, Q Qi; Hessel, Volker

doi:10.1071/ch12465

Cited by 40 publications

(18 citation statements)

References 71 publications

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“…However, using another solvent and at still higher pressure, some slight pressure effects were observed by Kobayashi et al, as the reaction time was reduced [64,95]. In the pressure range from 50 to 300 bar, the yield for the Claisen rearrangement was enhanced from 52 to 67 % (Fig.…”

Section: Pressure Effectsmentioning

confidence: 95%

The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow

et al. 2014

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In Part 2, the factors impacting the Claisen rearrangement both in batch and flow processing are analyzed, including the choice of substituent, catalyst, temperature, pressure, concentration, flow rates, and solvent. Part 1 of this review series discussed the potential of using short‐time spectroscopy and quantum mechanical calculations to elucidate the mechanism and transition state of the Claisen rearrangement. Flow processing offers profound opportunities for studying these factors known to impact the Claisen rearrangement done in batch. It is shown that the same impact factors also rule flow processing, yet now superposed by the very different residence and reaction time settings and by novel process windows which go beyond conventional processing. As a result, massive intensification can be reached and a mechanistic analysis can be done in entirely unpaved processing fields. This links to the analysis given in part 1: it is likely that flow processing can further promote the understanding of the mechanism and transition state of the Claisen rearrangement and, thereby, promote the achievement of better reaction performance.

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Section: Pressure Effectsmentioning

confidence: 95%

The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow

et al. 2014

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“…This concept of using unusual reaction conditions is also called Novel Process Windows, coined by Hessel. [12][13][14] The use of microreactor technology further provides enhanced process safety, high control over the reaction conditions, and increasing throughput by controlled scalability. According to a detailed investigation of Roberge et al, 50% of the reactions in the 4 pharmaceutical and fine chemical industry could benefit from a continuous process.…”

Section: Logistics/qualitymentioning

confidence: 99%

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

Noël

Hessel

2015

Organometallic Flow Chemistry

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Flow chemistry is typically used to enable challenging reactions which are difficult to carry out in conventional batch equipment. Consequently, the use of continuous-flow reactors for applications in organometallic and organic chemistry has witnessed a spectacular increase in interest from the chemistry community in the last decade. However, flow chemistry is more than just pumping reagents through a capillary and the engineering behind the observed phenomena can help to exploit the technology's full potential. Here, we give an overview of the most important engineering aspects associated with flow chemistry. This includes a discussion of mass-, heat-, and photon-transport phenomena which are relevant to carry out chemical reactions in a microreactor. Next, determination of intrinsic kinetics, automation of chemical processes, solids handling and multistep reaction sequences in flow are discussed. Safety is one of the main drivers to implement continuous-flow microreactor technology in an existing process and a brief overview is given here as well. Finally, the scale-up potential of microreactor technology is reviewed.

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“…This, in turn, allows for the use of reactants of higher concentration which leads to process intensification [21].…”

Section: Introductionmentioning

confidence: 99%

Magnetic actuation of catalytic microparticles for the enhancement of mass transfer rate in a flow reactor

Lisk

Bonnot

Rahman

et al. 2016

Chemical Engineering Journal

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Permanent WRAP URL:http://wrap.warwick.ac.uk/81857 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. AbstractThe effect of periodic changes in particle velocity on mass transfer to the reacting surface of a magnetic particle with a diameter 225 m in laminar flow has been investigated in a microfluidic reactor. The periodic particle motion in a fluid was investigated under a sinusoidal magnetic field generated by a quadrupole arrangement of electromagnets around the reactor. The effect of operating frequency of the rotating magnetic field, intensity of the magnetic field, and phase shift between the two sets of magnets on particle dynamics has been studied. Three particle motion modes have been observed depending on the frequency of the applied field. The mass transfer rate was estimated under steady velocity and variable velocity of the particle using a mass transfer correlation by Feng and Michaelides (Int. J. Heat Mass Transfer 44 (2001) 4445). The validity of this correlation for the case of variable particle velocity has been confirmed with a 2D numerical model, describing actual hydrodynamics and mass transfer towards the particle surface. The mass transfer coefficient *Revised Manuscript (clean for typesetting) Click here to view linked References 2 depends both on the mean particle velocity and the deviation of velocity from the mean value.The periodic movement with variable particle velocity reduces the mass transfer coefficient by 7.6% as compared to steady state motion with the same mean velocity.

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A View Through Novel Process Windows

Cited by 40 publications

References 71 publications

The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow

The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

Magnetic actuation of catalytic microparticles for the enhancement of mass transfer rate in a flow reactor

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