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SPDaily food intake w a s increased by 34% in insulin-treated rats and by 11% in the leptin-and insulin-treated rats (both ~~0 . 0 1 ) .Both insulin-treated groups gained more weight than the untreated controls (pCO.01). Daily blood glucose levels were reduced by 50% and plasma insulin levels raised 4-fold in both insulin-treated groups (all p

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Rat studies elucidating the mechanism by which fetal malnutrition increases the risk for glucose tolerance and type 2 diabetes are discussed.