One of the complications of pregnancy which is quite dangerous is preeclampsia. Increased blood pressure is a major indicator for pregnant women from preeclampsia. Various complications lead to increased risk of mortality and morbidity in the mother and fetus. During the birth process, the fetus that is conceived by a mother with preeclampsia, have a higher risk of developing neonatal asphyxia. This study aims was to determine the risk of preeclampsia on the incidence of neonatal asphyxia in dr. Sayidiman Magetan Hospital in 2018. The method used was observational with a cross sectional design. Data were collected using patient medical records. The results showed there was a difference in the incidence of neonatal asphyxia in preeclampsia and non- preeclampsia pregnant women (p = 0.000). Pregnant women with preeclampsia had a higher risk of giving birth with neonatal asphyxia (OR=3,071). In this study, it can be concluded that the risk of incidence of neonatal asphyxia is 3 times higher in preeclampsia than in non-preeclampsia at dr. Sayidiman Magetan in 2018.
Introduction: The number of infant mortality rates (IMR) in Indonesia still receives serious attention in health. The risk of increased infant mortality rates was found in infants with low birth weight. This happened because the baby will have growth and development problems, so they are more at risk of getting the disease. One of the causes of low-birth-weight babies is a history of preeclampsia during pregnancy. Objective: This study aims to determine the risk of preeclampsia on the increase in the incidence of low birth weight at the hospital. Method: This research method is observational with a cross-sectional design and using medical records at the hospital from 1 January 2018 to 31 December 2019 by comparing groups of pregnant women with mild and severe preeclampsia. Results and Discussion: Data obtained from medical records amounted to 210 people. The results showed a relationship between preeclampsia and the incidence of low birth weight (p = 0.000; r = 0.46). In addition, the risk of low-birth-weight infants in severe preeclampsia was higher than mild preeclampsia (OR = 11.5). Conclusion: This study concludes that the history of preeclampsia in pregnant women will increase the incidence of LBW babies. In addition, pregnant women with severe preeclampsia are 11.5 times more likely to have low birth weight babies than those with mild preeclampsia.
<p><strong>ABSTRAK</strong></p><p><strong><em>Latar Belakang:</em></strong><strong> </strong>Kondisi hiperglikemia tidak selalu terjadi pada penderita diabetes. Stress oksidatif merupakan salah satu proses pathogenesis yang ditimbulkan terhadap penyakit akibat hiperglikemia. Hal tersebut berkaitan dengan peningkatan Reactive Oxygen Species (ROS) dan penurunan aktivitas antioksidan. Pemberian asupan antioksidan dari luar tubuh diharapkan dapat membantu menetralisir radikal bebas yang berlebihan.</p><p><strong><em>Tujuan</em>:</strong> Untuk mengetahui efektivitas ektrak kulit jeruk nipis terhadap pernurunan radikal bebas pada kondisi hiperglikemia. </p><p><strong><em>Metode</em>:</strong> Penelitian ini merupakan eksperimental dengan post-test control group design dengan menggunakan tikus wistar di laboratorium Fakultas Kedkteran, Universitas Surabaya. Kondisi hiperglikemia pada hewan coba dilakukan melalui induksi aloksan dan selanjutnya diberikan ekstrak kulit jeruk nipis (2,35 mg; 4,7 mg; 9,4 mg) selama 30 hari dengan membagi menjadi 5 kelompok perlakukan. Parameter untuk mengetahui kadar radikal bebas pada penelitian ini adalah kadar malondialdehid.</p><p><strong><em>Hasil:</em></strong> Pada penelitian memperlihatkan bahwa pada kelompok yang diberikan ektrak kulit jeruk nipis akan mengalami penurunan kadar malondialdehid jika dibandingkan dengan kelompok lainnya (p<0,05). Hasil rerata kadar malondialdehid terendah pada dosis 9,4 mg (1,67±0,10).</p><p><em><strong>Kesimpulan:</strong></em> Pemberian ekstrak kulit jeruk nipis dapat menurunkan kadar malondialdehid pada kondisi hiperglikemia.</p><p> </p><p><strong>KATA KUNCI:</strong> <em>Citrus aurantifolia</em>; <em>hiperglikemia; malodialdehid; radikal bebas</em></p><p> </p><p> </p><p><strong>ABSTRACT</strong></p><p><strong><em>Background:</em></strong> Hyperglycemia condition does not always occur in diabetes. Oxidative stress is a process of pathogenesis diseases as a result of hyperglycemia. This is associated with increased Reactive Oxygen Species (ROS) and decreased antioxidant activity. Antioxidants intakes outside the body is expected to neutralize excessive free radicals.</p><p><em><strong>Objectives:</strong></em> To determine the effectiveness of lime peel extract against free radicals induced by hyperglycemia.</p><p><strong><em>Methods</em>:</strong> This research is an experimental post-test control group design using wistar rats in the laboratory of the Faculty of Medicine, University of Surabaya. Hyperglycemia conditions in experimental animals were carried out through alloxan induction and then given lime peel extract (2,35 mg; 4,7 mg; 9,4 mg) for 30 days by dividing into 5 treatment groups. The parameter to determine the levels of free radicals in this study is the levels of malondialdehyde</p><p><em><strong>Results:</strong> </em>Showed that the group given lime peel extract experienced a decrease in malondialdehyde levels when compared to the other groups (p<0.05). The lowest mean malondialdehyde level was at a dose of 9.4mg (1.67±0.10). </p><p><strong><em>Conclusion</em>:</strong> The administration of lime peel extract can reduce levels of Malondialdehyde induced by hyperglycemia.</p><p> </p><p><strong>KEYWORDS:</strong><em> Citrus aurantifolia; free radicals; hyperglycemia; malondialdehyde</em></p>
Background of Study: Globally, there are 19 million children with visual impairment, 12 million are caused by uncorrected refractive errors. Uncorrected refractive errors in children have the potential to cause amblyopia, severe visual impairment and even blindness. Refractive errors in children must receive proper management. Cycloplegic refraction is a gold standart method for children to minimize the effect of strong accommodation in childhood. The purpose of the study: to analyze the differences between the results of the visual acuity examination and refractive examination between the non-cycloplegic and the cycloplegic examination in children aged 4-12 years. Methods: This study is an analytical observational study through recording medical records of patients 4-12 y.o between November 2020-October 2021, which were carried out with non-cycloplegic and cycloplegic refraction. Data were analyzed by SPSS with WilcoxonTest. Results: There were 106 eyes of children consisting of 62(58%) boys and 44(42%) girls. Based on statistical tests, there was no difference in natural visual acuity on non-cycloplegic and cycloplegic examinations. There were differences between non-cycloplegic and cycloplegic refractions. The difference in refraction results towards the positive spherical 75(70,75%) children towards the negative spherical 21(19.81%) children, only 10(9,4%) children showed the same results between the two refractive stages. Conclusion: There was no difference in children's visual acuity between the non-cycloplegic examination and the cycloplegic examination, but there were differences in the results of non-cycloplegic and cycloplegic refraction in children aged 4-12 years. Therefore, the determination of the size of the glasses in children must be done through cycloplegic refraction.Keywords : Refraction, Cycloplegic Refraction, Visual Acquity, Children
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