BACKGROUND Diabetes mellitus and the complications associated with it has become a reason of concern due to health problems related to them. AIM To study and compare the pulmonary function parameters like FVC, FEV1, FEV1%, PEFR, FEV 25-75% in patients with type 2 diabetes mellitus and control group. SETTINGS AND DESIGN This study was planned to assess pulmonary functions in type 2 diabetic patients. METHODS AND MATERIALS We evaluated 60 diabetic male subjects in the age group 41-60 years. For controls, 60 age matched healthy male subjects were taken. PFT was carried out with Computerised Medspiror. STATISTICAL ANALYSIS The various data was collected, compiled, statistically analysed by unpaired t-test and conclusion drawn. RESULTS The present study results showed a significant decrease in the mean values of FVC, FEV1, PEFR and FEF 25-75% in diabetic subjects as compared to controls. FEV1% was significantly increased in diabetic persons. CONCLUSION Chronic hyperglycaemia leads to non-enzymatic glycosylation of extracellular matrix leading decrease in lung compliance, which is responsible for restrictive type of pulmonary impairment of lung functions.
Background: Women undergo many types of behavioral and hormonal changes, especially during reproductive life. Besides reproductive changes, there occur cyclical fluctuations in various functions of body systems. Autonomic nervous system provides physiological adaptive background for these changes. In these cyclical changes, pre-menstrual phase stress can be assessed by sympathetic function tests to avoid further cardiovascular complications. Aims and Objectives: The aim of the study is to carry out sympathetic function tests during pre-menstrual phase and post-menstrual phase of healthy young women. Materials and Methods: The study was carried out in 50 healthy females of age between 18 and 25 years. They undergo the sympathetic function tests such as pulse rate, blood pressure (BP), orthostatic variation on BP, and cold pressor test. Statistical analysis was done by student paired t-test. Result: Response to various sympathetic tests were altered in pre-menstrual phase as compared to that of post-menstrual phase reflecting highly significant increase in the sympathetic activity. Conclusion: Neurohormonal changes and pre-menstrual stress during the pre-menstrual phase are interrelated to each other and increases the sympathetic activity.
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