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BACKGROUND In India, most of the anti-tuberculosis regimens under Revised National Tuberculosis Control Programme (RNTCP) are rifampicin based. Venous Thrombosis (VT) is a rare side effect of rifampicin and very few cases are reported worldwide. Studies have demonstrated possible association between VT and use of rifampicin, in patients treated with rifampicin containing regimens. MATERIALS AND METHODS This was an observational study done in New Medical College Hospital, Kota during the period June 2016 to July 2018. Careful watch was kept on patients who were admitted for any complications after initiation of ATT. RESULTS During this period, 4 patients, who were taking ATT, presented with thromboembolic events. Mean time of presentation was 71±22 days after starting ATT. 3 patients had lower limb DVT & 1 patient had pulmonary artery thrombus. CONCLUSION Though venous thrombosis is uncommon side effect of rifampicin, treating physicians should be cautious during treatment.

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Pericardial effusion is not so uncommon in hypothyroidism, but pericardial tamponade is very rare entity. Hypothyroidism complicated by pericardial tamponade is very rarely referenced in the medical literature. Here we report a rare case of a 70 year old female, who presented with breathlessness and was found to have hypothyroidism with large pericardial effusion complicating into pericardial tamponade. Management included urgent pericardiocentesis followed by l-thyroxine supplementation.

Background: Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion, and reflects iron stores of the body. Recent studies indicate that increased body iron stores are associated with development of type 2 diabetes mellitus (DM) hence affecting the level of glycated haemoglobin. The aim and objectives of this study were to determine the relationship between serum ferritin and glycated haemoglobin in type 2 diabetes patients and to find out correlation between serum ferritin level and components of metabolic syndrome.Methods: This study included 100 cases of type 2 DM compared with age and sex-matched 100 non-diabetic controls. Serum ferritin, fasting blood sugar, lipid parameters and waist circumference were estimated, and glycated haemoglobin was calculated by HPLC method.Results: The mean serum ferritin in cases was 178.59±84.17 µg/l and in controls was 107.17±13.83 µg/l (p=0.0001). The mean age was 53.32±10.14 years in cases and 51.8±10.54 years in controls. Mean HbA1C level in cases was higher (8.40±1.22) as compared to controls (5.4±0.34) and it was statistically significant (p<0.0001). There was a positive linear correlation between HbA1C level and serum ferritin irrespective to gender in case group (r=0.342) and it was statistically significant (p<0.0001). Serum ferritin was significantly higher in hypertensive type 2 DM patients than hypertensive non-diabetic patients (p<0.0239).Conclusions: The findings of this study suggest that increased level of serum ferritin is positively related to glycaemic control.

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Primaquine is used in prevention of relapse of plasmodium vivax and ovale. It is known to cause haemolysis induced acute kidney injury in patients with glucose-6-phosphate dehydrogenase (G-6-PD) enzyme deficiency. Primaquine is widely used in the remote areas of Hadoti region of India by many non-registered practitioners for treatment of febrile illnesses without prior testing of G-6-PD status. Due to this practice, many patients land up with the grave consequences with significant health care burden. We report 8 such cases, which were referred to our hospital, New hospital medical college, Kota, Rajasthan, India. Our study included a series of 8 cases which were referred to our hospital with significantly deranged renal function test due to use of primaquine without prior testing of G-6-PD status. Routine blood investigations including renal function tests and G-6-PD status were measured. In our study, we found that patients with febrile illness and G-6-PD deficiency developed acute kidney injury even with a single tablet of 15 mg of primaquine. The use of even a single dose of 15 mg primaquine may not be safe in population of Hadoti region of India. Hence they should not be exposed to primaquine without prior G-6-PD testing.