PurposeTo evaluate the performance of delefilcon A water gradient and narafilcon A silicone hydrogel daily dispos-able contact lenses (CLs) in symptomatic soft CL wearers. MethodsThis multicenter, open-label, crossover study randomized 121 soft CL wearers with symptoms of CL dis-comfort to delefilcon A or narafilcon A for 2 weeks, followed by the alternate lens for 2 weeks. Subjects rated end-of-day (EOD) comfort, EOD dryness, and quality of vision, and investigators rated fit, surface deposits, and surface wettability. ResultsAfter 2 weeks, all subjective measures were better for delefilcon A than for narafilcon A, including EOD comfort (8.3 ± 1.9 vs. 6.6 ± 2.2), EOD dryness (8.0 ± 2.2 vs. 5.8 ± 2.6), and quality of vision (8.9 ± 1.4 vs. 7.9 ± 1.7), all p<.0001. Average daily wear time (DWT; 13.0 ± 2.8 vs. 12.3 ± 2.6 hr) and average comfort-able DWT (11.6 ± 3.9 vs. 9.3 ± 3.8 hr) were longer for delefilcon A lenses (p<.0001). The proportions of right and left lenses without front surface deposits were twofold higher for delefilcon A than for narafilcon A, and surface wettability was significantly higher for delefilcon A than for narafilcon A p<.0001). ConclusionIn this population of symptomatic CL wearers, delefilcon A lenses showed superior subjective ratings for comfort, dryness, quality of vision, DWT, and comfortable DWT and better investigator-rated lens sur-face attributes including fewer surface deposits and superior wettability than did narafilcon A lenses after 2 weeks of wear.
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