Performance of Daily Disposable Contact Lenses in Symptomatic Wearers

Abstract

PurposeTo evaluate the performance of delefilcon A water gradient and narafilcon A silicone hydrogel daily dispos-able contact lenses (CLs) in symptomatic soft CL wearers.
 MethodsThis multicenter, open-label, crossover study randomized 121 soft CL wearers with symptoms of CL dis-comfort to delefilcon A or narafilcon A for 2 weeks, followed by the alternate lens for 2 weeks. Subjects rated end-of-day (EOD) comfort, EOD dryness, and quality of vision, and investigators rated fit, surface deposits, and surface wettability.
 ResultsAfter 2 weeks, all subjective measures were better for delefilcon A than for narafilcon A, including EOD comfort (8.3 ± 1.9 vs. 6.6 ± 2.2), EOD dryness (8.0 ± 2.2 vs. 5.8 ± 2.6), and quality of vision (8.9 ± 1.4 vs. 7.9 ± 1.7), all p<.0001. Average daily wear time (DWT; 13.0 ± 2.8 vs. 12.3 ± 2.6 hr) and average comfort-able DWT (11.6 ± 3.9 vs. 9.3 ± 3.8 hr) were longer for delefilcon A lenses (p<.0001). The proportions of right and left lenses without front surface deposits were twofold higher for delefilcon A than for narafilcon A, and surface wettability was significantly higher for delefilcon A than for narafilcon A p<.0001).
 ConclusionIn this population of symptomatic CL wearers, delefilcon A lenses showed superior subjective ratings for comfort, dryness, quality of vision, DWT, and comfortable DWT and better investigator-rated lens sur-face attributes including fewer surface deposits and superior wettability than did narafilcon A lenses after 2 weeks of wear.

Relationships between the material properties of silicone hydrogels: Desiccation, wettability and lubricity

“…The DelA superior lubricity and wettability in the course of extended desiccation/rehydration cycling in vitro also aligned with the clinical observation that in population of symptomatic CL wearers, delefilcon A lenses showed superior subjective ratings for comfort, dryness, quality of vision, comfort daily wear time, and better lens surface attributes including fewer surface deposits and superior wettability than did narafilcon A lenses after 2 weeks of wear. 49 The result agrees well with the relatively high CoF of stenfilcon A even after shorter exposure to dryness (t < 4 h). Thus the importance of true coating for the long term control of SiHy surface properties is emphasized as compared to implementation of (internal) wetting agents and to alterations of bulk Si content.…”

“…Thus it highlights that in lack of surface modifications and/or instillation of wetting agents the low bulk Si content may not guarantee distinct performance of the SiHy surface, as especially at extended wear, the desiccation may "extract" Si moieties from the bulk to the surface of the SiHy. It is important to note that the superior in vitro wettability of DelA against the rest of the SiHy studied, was recently confirmed in in vivo quantification of contact lens wettability under low humidity conditions 48 where "delefilcon A performed better than stenfilcon A and narafilcon A after 6 hrs of wear including 3 hrs intensive visual tasks under challenging environmental conditions". The DelA superior lubricity and wettability in the course of extended desiccation/rehydration cycling in vitro also aligned with the clinical observation that in population of symptomatic CL wearers, delefilcon A lenses showed superior subjective ratings for comfort, dryness, quality of vision, comfort daily wear time, and better lens surface attributes including fewer surface deposits and superior wettability than did narafilcon A lenses after 2 weeks of wear.…”

“…The DelA superior lubricity and wettability in the course of extended desiccation/rehydration cycling in vitro also aligned with the clinical observation that in population of symptomatic CL wearers, delefilcon A lenses showed superior subjective ratings for comfort, dryness, quality of vision, comfort daily wear time, and better lens surface attributes including fewer surface deposits and superior wettability than did narafilcon A lenses after 2 weeks of wear. 49 …”

Significances of Daily Disposable Contact Lenses During Covid-19

“…So, users usually rub the eyes and adnexa frequently to relieve the symptoms which might induce the suspected coronavirus to the eyes .6 Daily disposable contact lenses and COVID-19: Recent literatures have suggested that with compared to conventional or yearly disposable contact lenses, daily disposable lenses are safer during COVID-19. 4,7 So all the contact lens users should be motivated to use disposable lenses taken every day from a sterile package and which are discarded at the end of the wear in evening to minimize the risk of Coronavirus contamination. Such lenses can be more hygienic than conventional wear design because lens is always placed directly on the eye fresh from a blister pack solution such that leaching agents in the lens are optimal.…”

“…5 Daily disposable are less likely to dehydrate and may render them more deposit resistant and comfortable for the wearer. 4 These lenses are made from novel materials including higher water content with gradient technologies and designs which could enhance their wearing comfort with less prone to deposits. Since lenses are packaged in individual blister packs in an unpreserved solution, solution sensitivity is far reduced.…”