Breast cancer is the most prevalent form of cancer among women. Non-invasive and early stage diagnosis of breast cancer would be pragmatic to reduce unnecessary biopsy and mortality rate. We propose Wigner-Ville distribution (WVD) based photoacoustic spectral response (WVD-PASR), a tissue elasticity dependent technique for human breast cancer diagnosis. Since tissue elasticity acts as a finger print of many diseases including cancer, the proposed technique would differentiate normal from malignant breast masses. In addition, WVD is an advanced signal processing tool for timefrequency analysis which provides frequency domain parameters along with time information. This feature of WVD would elicit critical information about frequency component of the PA time domain signal. Since frequency content of PA signal is related to tissue elasticity, WVD-PASR would differentiate human breast masses. Applying the proposed technique on normal and malignant human breast tissues reveals that frequency analysis of malignant tissues contain two dominant peaks as compared to one dominant peak for a normal tissue. Besides having two dominant frequencies, the energy density of malignant breast is significantly more than that of normal tissue. Hence the proposed tool, in addition to detection of malignant breast tumours, could also provide tissue elasticity and other mechano-biological properties.
We present the development of a laser diode based photoacoustic spectral response (PASR) setup capable of diagnosing human breast cancer tissues through the use of mechanobiological properties of the tissue. A detailed description of the laser driver is provided, highlighting the important characteristics of the developed driver. Furthermore, the amplifier development is described. The developed laser diode based PASR system has been characterized using standard samples. Subsequently, the developed experiment has been applied onto diagnosis of human breast tumors. Energy has been used as a parameter to differentiate between normal and malignant tissues. The results were statistically consistent and then compared with standard histopathology for correlation.
A case of embryonal rhabdomyosarcoma of the middle ear presenting with facial paralysis and a polypoidal aural mass who subsequently had convulsions due to intracranial extension is presented for its rarity.
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