Development of a compact laser-diode based frequency domain photoacoustic sensing system: Application of human breast cancer diagnosis

Gorey, Abhijeet; Vasudevan, Srivathsan; Ansari, M. S.; Bhagat, Priyanka; Phatak, Satish; Sharma, Norman; Chen, George C. K.

doi:10.1063/1.5093698

Cited by 11 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PA time domain signal was obtained from biopsy excised breast tissue in continuous mode. Further spectral energy was calculated from PA frequency spectra of normal and malignant tissues, which illustrated that malignant tissues elucidate higher spectral energy compared to normal tissues [126]. Choi et al reported wavelength modulated differential photoacoustic spectroscopy (WM-DPAS) for early-stage cancer diagnosis through change in total hemoglobin concentration and oxygenation levels (StO 2 ).…”

Section: Cancer Diagnosismentioning

confidence: 99%

Biomedical Application of Photoacoustics: A Plethora of Opportunities

2022

Self Cite

View full text Add to dashboard Cite

The photoacoustic (PA) technique is a non-invasive, non-ionizing hybrid technique that exploits laser irradiation for sample excitation and acquires an ultrasound signal generated due to thermoelastic expansion of the sample. Being a hybrid technique, PA possesses the inherent advantages of conventional optical (high resolution) and ultrasonic (high depth of penetration in biological tissue) techniques and eliminates some of the major limitations of these conventional techniques. Hence, PA has been employed for different biomedical applications. In this review, we first discuss the basic physics of PA. Then, we discuss different aspects of PA techniques, which includes PA imaging and also PA frequency spectral analysis. The theory of PA signal generation, detection and analysis is also detailed in this work. Later, we also discuss the major biomedical application area of PA technique.

show abstract

Section: Cancer Diagnosismentioning

confidence: 99%

Biomedical Application of Photoacoustics: A Plethora of Opportunities

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…(17). 15 – 20 For the specialized LED/LD module having a very high repetition rate, like a few hundred KHz, the

becomes very low, like a few ten-thousandth, 21 which makes

increased up to a few tens of MHz. Therefore, it is reasonable to consider that achieving the maximum repetition rate or, equivalently, the maximum pulse number is almost impossible for almost all practical LED/LD-based PA systems.…”

Section: Snr Ratio For Pulse Train and Chirp Waveformsmentioning

confidence: 99%

“…However, due to existing conventional thought that pulse PA signals exhibit higher SNRs than continuous ones, the majority of LED/LD-based PA imaging studies have been conducted with pulse-mode or pulse LDs. 14 , 16 – 18 The usage of pulse LDs limits the development of PA spectroscopic imaging systems because the typical wavelength of most commercially available pulse LDs is in the range of near-infrared more than

. 15 , 17 , 18 Additionally, most pulse LDs operate with a very low power per pulse, which could lead to the reduction of overall fluence and real-time PA measurement capability.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic signal-to-noise ratio comparison for pulse and continuous waveforms of very low optical fluence

Kang

2022

J. Biomed. Opt.

View full text Add to dashboard Cite

. Significance: A majority in the photoacoustic (PA) community unconditionally accepts that pulse PA signals show much higher signal-to-noise ratios (SNRs) than continuously excited PA signals. However, we indicate this existing notion would not be valid for very low optical-fluence light-emiting diodes (LEDs)/laser diodes (LDs)-based PA systems. Aim: We demonstrate in theory and simulation that when the optical fluence of PA-excitation waveforms is much lower than the American National Standards Institute (ANSI) maximum permission exposure (MPE), matched filtered PA signals from chirp waveforms show higher SNRs than those of pulse train waveforms. Approach: We theoretically derive the PA SNR expression considering the pulse fluence reduction factor based on the ANSI MPE. We investigate and analyze SNR ratios of the pulse train and chirp-waveform matched filtered PA signals with conceptual understanding. We also perform brute-force simulations to extract PA SNRs for the verification of the result. Results: The brute-force simulations show that the matched filtering with chirp waveforms could achieve better SNRs than pulse train waveforms for very low-fluence PA systems. As the fluence is smaller, the SNR of the matched filtered PA signals is more dominant than that of pulse trains in a wider PA data acquisition time range. In addition, estimated SNR ratios adopting actual parameters of LED/LD-based pulse train PA systems in previous literature support the finding of this paper. Conclusions: The result can extend the possibility of applying various continuous waveform techniques already studied in the conventional radar technology to PA systems of limited optical power, which would diversify and expedite the research and development of LED/LD-based, compact, and cost-effective PA systems.

show abstract

Photoacoustic spectroscopy of food stuff

Dwivedi¹

2023

Photoacoustic and Photothermal Spectroscopy

View full text Add to dashboard Cite

Development of a compact laser-diode based frequency domain photoacoustic sensing system: Application of human breast cancer diagnosis

Cited by 11 publications

References 17 publications

Biomedical Application of Photoacoustics: A Plethora of Opportunities

Biomedical Application of Photoacoustics: A Plethora of Opportunities

Photoacoustic signal-to-noise ratio comparison for pulse and continuous waveforms of very low optical fluence

Photoacoustic spectroscopy of food stuff

Contact Info

Product

Resources

About