An elegant approach was presented for the synthesis of novel α‐aminophosphonates: a three‐component one‐pot condensation of 3‐(trifluoromethyl)aniline, substituted aromatic aldehydes, and diethyl phosphite using a nickel‐based metal–organic framework (Ni‐MOF). The Ni‐MOF was synthesized using 4,4′‐biphenyldicarboxylic acid and further characterized using various techniques such as X‐ray diffraction, Fourier‐transform infrared, thermogravimetry/differential thermal analysis, Brunauer–Emmett–Teller, and field‐emission scanning electron microscopy analyses. Ni‐MOF seems to be an eco‐friendly, an easily recyclable, and heterogeneous catalyst up to the eighth run with minimal reduction in its catalytic activity. The synthesized α‐aminophosphonates were also investigated for antibacterial and antioxidant activities. In few cases, compounds 4a–4x show similar as well as higher antibacterial activity. Among the synthesized α‐aminophosphonates, 4a–4x had more potent antibacterial activity against pathogenic bacteria while compounds 4h, 4m, 4n, 4q, 4u, 4v, and 4w exhibited significant antioxidant activity.
A series of novel α-aminophosphonate derivatives were synthesized via simple and an efficient method from the threecomponent condensation reaction of 5-aminoindan or 3,4-(methylenedioxy)aniline, aromatic aldehydes and diethyl phosphite by employing graphene nanosheets-silver nanoparticles (GNS-AgNPs) as catalyst under ultrasonication and solvent-free condition. GNS-AgNPs was prepared in situ by simultaneous reduction of graphene oxide (GO) and silver nitrate (AgNO 3 ) using sodium borohydride (NaBH 4 ) as a reducing agent. The surface characterization of GNS-AgNPs was done using X-ray diffraction (XRD), Fourier transform infrared (FTIR), UV-Vis spectroscopy (UV-Vis), Thermogravimetric analysis (TGA), Raman spectroscopy and Field emission scanning electron microscopy (FE-SEM). The GNS-AgNPs are recyclable up to fifth run with minimal loss of its activity. Convenient operational simplicity, mild conditions, excellent yields of products, consistent performance and the reusability of catalyst makes this protocol feasible and attractive.
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