Program pengelolaan penyakit kronis (Prolanis) ditujukan kepada peserta usia diatas 60 tahun. Jenis penyakit yang termasuk dalam prolanis diantaranya hipertensi dan diabetes. Berdasarkan data Dinas Kesehatan (DINKES) Kabupaten Cilacap tahun 2018, hipertensi esensial menduduki urutan ke 5 dari 10 penyakit terbanyak dengan jumlah kasus hipertensi sebanyak 18.016 kasus. Jumlah kasus diabates melitus di Kabupaten Cilacap tahun 2018 sebanyak 4.806 kasus. Tujuan penelitian ini untuk mengatahui pola peresepan obat diabetes melitus dan obat hipertensi pasien lansia peserta prolanis, mengetahui obat-obat yang berpotensi menimbulkan ketidaktepatan bila digunakan pada lansia berdasarkan kriteria beers 2019. Metode yang digunakan dalam penelitian ini adalah metode deskriptif non analitik, data dikumpulkan secara retrospektif. Hasil penelitian menunjukan pola peresepan obat diabetes melitus oral yaitu metformin 47 resep (16,85%), glimepirid 38 resep (13,62%). Terapi kombinasi obat diabetes melitus yaitu metformin dengan glimepirid 136 resep (48,75%). Pola peresepan obat hipertensi oral yaitu amlodipin 184 resep (66,95%), Irbesartan 10 resep (3,58%), captopril 10 resep (3,58%). Terapi kombinasi terbanyak yaitu amlodipin dengan irbesartan sebanyak 18 resep (6,45%). Hasil analisis berdasarkan kriteria beers 2019 yaitu glimepirid 221 resep (98,23%), clonidin 2 resep (0,89%), glibenklamid 1 resep (0,44%) dan glimepirid dengan clonidin 1 resep (0,44%).
Introduction: Dengue NS1 Antigen (NS1 Ag) detection or quantification has become a specific diagnostic tool for dengue virus infection, but has variable sensitivity. Previous research reported NS1 Ag level can be detected up to the 7th–10th day of fever, others stated the sensitivity was decreased after four days of fever. We performed this research to analyze the NS1 Ag profile and its relationship with the day of illness.Methods: This study was a prospective cohort study on 39 children hospitalized at Dr. Soetomo Hospital Surabaya since November 2009 to May 2010. Inclusion criteria were acute fever less than 72 hours, bleeding tendency denoted at least by positive tourniquet test, age between 1–14 years, and confirmed by positive dengue IgM/IgG on the 5th day of fever. We performed daily quantitative dengue NS1 Ag tests until defervescence day, and its relationship with the day of illness were analyzed.Results: NS1 Ag was positive in 19/39 samples. Secondary infection occurred in 14/19 of Dengue Fever and 17/20 of Dengue Hemorrhagic Fever cases. Positivity of NS1Ag was higher in primary (6/8 cases) than secondary infection (12/31 cases). Mean level of NS1 Ag was highest on the 2nd day, decreased afterwards and undetected on the 5th day of fever. There was significant relationship between NS1 Ag positivity (P=0.037, rs=-0.9) and level (P<0.001, rs=-1) with the day of illness.Conclusion: Dengue NS1 Ag positivity and level were highest during the acute phase of fever and decreased afterwards.The Relationship of Ns1 Antigen Profi Le and Days of Illness in Children with Dengue Virus Infection
Nit-Occlud Le VSD coil, an alternative device for closing VSD transcatheter, started to be used in dr. Soetomo Hosptal in 2017, but no research has been done on the results of closure with this device. This study aims to evaluate the efficacy and safety of the Nit-Occlud Le VSD coil. Descriptive observational method was used. The results are as follow: Of the 17 patients who underwent transcatheter closure during January to December 2018, 10 (58, 8%) cases were closed with Nit- Occlud Le VSD coil. The success of implantation is 100%, 8 cases were closed with Nit-Occlud Le VSD coil, 2 plus an amplatzer (ADO 1 and AVSO). Type of VSD: perimembranaous 7 (70%), subaortic 2 (20%) and mid muscularis 1 (10%). Immediate complete closure in 7/10 (70%), while 3 (30%) obtained residual DSV. The closure rate at the first month of follow up becomes 80%. Median length of post-catheterization was 2 days (2 - 3 days). Complications: 1 (10%) mild aortic regurgitation, 1 (10%) hemolysis and 2 (20%) with additional second device (ADO 1 and AVSO): first case: moderate residual VSD and severe aortic regurgitation; second case: severe tricuspid regurgitation and residual VSD that disappeared in first month. The residual VSD altered from 30% to 10%, and closure rate was 80% at the first month of observation. VSD closure with Nit-Occlud Le VSD coil provides good efficacy and safety for patients. Keywords: VSD, Nit-Occlud Le VSD coil.
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