Os anti-inflamatórios não esteroidais (AINEs) constituem atualmente a classe de medicamentos mais comumente prescrita no mundo todo. A frequência do seu uso tem crescido bastante nos últimos anos. A relação entre o uso de AINEs e a insuficiência renal já está bastante estabelecida e resulta de alterações na vasodilatação renal compensatória, além da liberação de citocinas pró-inflamatórias que causam lesão glomerular. O comprometimento renal constitui um dos principais responsáveis pelo alto índice de morbimortalidade associada ao uso indiscriminado dos AINEs. No presente artigo realizamos uma revisão da literatura existente acerca da nefrotoxicidade causada pelo uso dos AINEs, analisando a fisiopatologia e as principais manifestações clínicas das diversas formas de acometimento renal
The aim of this study was to evaluate renal function in patients with psoriasis using
immunobiologicals. A prospective study was conducted with 15 patients with confirmed
diagnosis of psoriasis who were starting to use immunobiologicals. The mean age was
41±11 years, with 60% females. The mean time of disease was 11±6.6 years. Significant
changes in creatinine and creatinine clearance were not observed in the course of the
study. There was an increase in transaminases and a decrease in magnesium levels.
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