Evaluation of renal function in patients with psoriasis using immunobiologicals

Abstract

The aim of this study was to evaluate renal function in patients with psoriasis using immunobiologicals. A prospective study was conducted with 15 patients with confirmed diagnosis of psoriasis who were starting to use immunobiologicals. The mean age was 41±11 years, with 60% females. The mean time of disease was 11±6.6 years. Significant changes in creatinine and creatinine clearance were not observed in the course of the study. There was an increase in transaminases and a decrease in magnesium levels.

Tumor Necrosis Factor α Blockade to Ameliorate Renal ischemia Reperfusion Injury

“…The spectrum of extrarenal adverse effects does not seem to differ much from that of other biologicals. 10 Yet, blocking one of the main proinflammatory cytokines in addition to the standard immunosuppressive regimen, mainly directed against T cell function, may inflict a higher rate of infectious complications particularly in the early posttransplant stage.…”