These findings suggest that over-expression of sphingosine kinase-1 in human endothelial cells promotes, in part, their de-differentiation to a progenitor cell phenotype, and is thus a potential tool for the generation of a large population of vascular progenitor cells for therapeutic use.

., 2012. The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3), 448-450. DOI: doi:10.1136448-450. DOI: doi:10. /bjophthalmol-2011 ©BMJ Group 2012. Please note that any alterations made during the publishing process may not appear in this version. Results All allografts underwent rejection. The median time to rejection for unmodified allografts was day 15, compared with day 14.5 for minimally lymphadenectomised recipients and day 18 for more extensively lymphadenectomised recipients (p>0.05, all comparisons).cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3), 448-450. Paper reproduced here in accordance with the publisher's policies.The median day to rejection for the combined group of lymphadenectomised rats was day 17 (p>0.05 compared with unmodified grafts). The rejection process was similar in all recipients. ConclusionsRemoval of multiple lymph nodes in the neck and thorax did not significantly influence the incidence, tempo or nature of the corneal allograft response. Sensitisation and clonal expansion of corneal alloantigen-reactive cells cannot occur only in superficial cervical, facial, internal jugular and posterior cervical lymph nodes in the rat.Archived at Flinders University: dspace.flinders.edu.au Brice, S. L.; Kirk, K.; Brereton, H. M.; Coster, D. J.; Williams, K. A. The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3), 448-450. Paper reproduced here in accordance with the publisher's policies.

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