The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats: Table 1

Abstract

., 2012. The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3), 448-450. DOI: doi:10.1136448-450. DOI: doi:10. /bjophthalmol-2011 ©BMJ Group 2012. Please note that any alterations made during the publishing process may not appear in this version. Results All allografts underwent rejection. The median time to rejection for unmodified allografts was day 15, compared with day 14.5 for minimally lymphadenectomised recipients and day 18 for more extensively lymphadenectomised recipients (p>0.05, all comparisons).cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3), 448-450. Paper reproduced here in accordance with the publisher's policies.The median day to rejection for the combined group of lymphadenectomised rats was day 17 (p>0.05 compared with unmodified grafts). The rejection process was similar in all recipients. ConclusionsRemoval of multiple lymph nodes in the neck and thorax did not significantly influence the incidence, tempo or nature of the corneal allograft response. Sensitisation and clonal expansion of corneal alloantigen-reactive cells cannot occur only in superficial cervical, facial, internal jugular and posterior cervical lymph nodes in the rat.Archived at Flinders University: dspace.flinders.edu.au Brice, S. L.; Kirk, K.; Brereton, H. M.; Coster, D. J.; Williams, K. A. The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats. British Journal of Ophthalmology, 96(3), 448-450. Paper reproduced here in accordance with the publisher's policies.

Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats

“…In the mouse, bilateral removal of the cervical lymph nodes induces indefinite corneal graft survival across a weak histocompatibility barrier 20. However, we have reported that the bilateral removal of some or all of the superficial cervical, facial, internal jugular and posterior cervical lymph nodes prior to corneal transplantation has no effect on the tempo or incidence of immunological rejection in the inbred WF/F344 combination 21. T cell sensitisation may occur within the eye, its environs, in other lymph nodes or the spleen.…”

Strategies for local gene therapy of corneal allograft rejection

“…Nonetheless, these steps typically occur centrally, and local transgene products may be inadequate. A recent study designed to investigate the effects of cervical and thoracic lymphadenectomy on corneal graft rejection in inbred rats failed to demonstrate any difference 21. The authors suggest that sensitization and clonal expansion of corneal alloantigen-reactive cells may not be limited only to the regional lymph nodes (superficial cervical, facial, internal jugular, and posterior cervical) in rat.…”

The changing face of corneal graft rejection

“…In this issue of the BJO , Brice et al 19 have considered the intervention of regional lymph node extirpation to modulate the immune response by eliminating the site of antigen presentation and clonal expansion of effector lymphocytes. Despite the volume of effort directed towards modulating the immune system, the most significant impact on reducing the incidence of corneal graft rejection has come from an unexpected source: the surgical innovation of lamellar corneal graft surgery.…”