Applied visualization researchers often work closely with domain collaborators to explore new and useful applications of visualization. The early stages of collaborations are typically time consuming for all stakeholders as researchers piece together an understanding of domain challenges from disparate discussions and meetings. A number of recent projects, however, report on the use of creative visualization-opportunities (CVO) workshops to accelerate the early stages of applied work, eliciting a wealth of requirements in a few days of focused work. Yet, there is no established guidance for how to use such workshops effectively. In this paper, we present the results of a 2-year collaboration in which we analyzed the use of 17 workshops in 10 visualization contexts. Its primary contribution is a framework for CVO workshops that: 1) identifies a process model for using workshops; 2) describes a structure of what happens within effective workshops; 3) recommends 25 actionable guidelines for future workshops; and 4) presents an example workshop and workshop methods. The creation of this framework exemplifies the use of critical reflection to learn about visualization in practice from diverse studies and experience.

This is the accepted version of the paper.This version of the publication may differ from the final published version. Abstract-We enhance a user-centered design process with techniques that deliberately promote creativity to identify opportunities for the visualization of data generated by a major energy supplier. Visualization prototypes developed in this way prove effective in a situation whereby data sets are largely unknown and requirements open -enabling successful exploration of possibilities for visualization in Smart Home data analysis. The process gives rise to novel designs and design metaphors including data sculpting. It suggests: that the deliberate use of creativity techniques with data stakeholders is likely to contribute to successful, novel and effective solutions; that being explicit about creativity may contribute to designers developing creative solutions; that using creativity techniques early in the design process may result in a creative approach persisting throughout the process. The work constitutes the first systematic visualization design for a data rich source that will be increasingly important to energy suppliers and consumers as Smart Meter technology is widely deployed. It is novel in explicitly employing creativity techniques at the requirements stage of visualization design and development, paving the way for further use and study of creativity methods in visualization design. Permanent repository link

Showing flows of people and resources between multiple geographic locations is a challenging visualisation problem. We conducted two quantitative user studies to evaluate different visual representations for such dense many-to-many flows. In our first study we compared a bundled node-link flow map representation and OD Maps [37] with a new visualisation we call MapTrix. Like OD Maps, MapTrix overcomes the clutter associated with a traditional flow map while providing geographic embedding that is missing in standard OD matrix representations. We found that OD Maps and MapTrix had similar performance while bundled node-link flow map representations did not scale at all well. Our second study compared participant performance with OD Maps and MapTrix on larger data sets. Again performance was remarkably similar.

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Comparing multiple variables to select those that effectively characterize complex entities is important in a wide variety of domains - geodemographics for example. Identifying variables that correlate is a common practice to remove redundancy, but correlation varies across space, with scale and over time, and the frequently used global statistics hide potentially important differentiating local variation. For more comprehensive and robust insights into multivariate relations, these local correlations need to be assessed through various means of defining locality. We explore the geography of this issue, and use novel interactive visualization to identify interdependencies in multivariate data sets to support geographically informed multivariate analysis. We offer terminology for considering scale and locality, visual techniques for establishing the effects of scale on correlation and a theoretical framework through which variation in geographic correlation with scale and locality are addressed explicitly. Prototype software demonstrates how these contributions act together. These techniques enable multiple variables and their geographic characteristics to be considered concurrently as we extend visual parameter space analysis (vPSA) to the spatial domain. We find variable correlations to be sensitive to scale and geography to varying degrees in the context of energy-based geodemographics. This sensitivity depends upon the calculation of locality as well as the geographical and statistical structure of the variable.

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Constraint programming allows difficult combinatorial problems to be modelled declaratively and solved automatically. Advances in solver technologies over recent years have allowed the successful use of constraint programming in many application areas. However, when a particular solver's search for a solution takes too long, the complexity of the constraint program execution hinders the programmer's ability to profile that search and understand how it relates to their model. Therefore, effective tools to support such profiling and allow users of constraint programming technologies to refine their model or experiment with different search parameters are essential. This paper details the first user-centred design process for visual profiling tools in this domain. We report on: our insights and opportunities identified through an on-line questionnaire and a creativity workshop with domain experts carried out to elicit requirements for analytical and visual profiling techniques; our designs and functional prototypes realising such techniques; and case studies demonstrating how these techniques shed light on the behaviour of the solvers in practice.