The present research examined the interaction between the skill level of a model (an expert or learning model) and a learning schedule (alternating observation and practice; or concentrated observation and practice, respectively) on acquiring a new bimanual pattern of 90 degrees relative phase. Five groups were compared: alternating-expert, alternating-learning, concentrated-expert, concentrated-learning and physical practice only. The concentrated-learning group performed better than alternating-expert, alternating-learning, as well as physical practice only learning schedule groups in retention tests. This seemed to arise from the effectiveness of concentrated observation throughout the improvement processes exhibited by the learning model.
With an aim to develop a new approach to synthesize 4'-substituted nucleosides, reactions of thymidine derivatives having a benzenesulfonyl leaving group at the 4'-position with organosilicon and organoaluminum reagents were investigated. Two substrates 4alpha (alpha-L-isomer) and 4 beta (beta-D-isomer) were prepared for this purpose. Although reaction of 4alpha with organosilicon reagents gave preferentially the 4'-substituted (allyl and N(3)) beta-D-nucleoside, its reaction with AlMe(3) gave the 4'-methyl-alpha-L-thymidine as the major product. On the other hand, the substrate 4beta, upon reacting with AlMe(3), furnished the desired 4'-methylthymidine exclusively in high yield.
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