A Multidisciplinary Research Programme (MRP) is being developed since 1989 in the Universidad Complutense de Madrid (UCM), Spain, to support cross-disciplinary research projects. This paper analyses the incidence of interdisciplinarity in the UCM scientific publications over the period 1990-96 and tries to determine the success of the Programme at fostering cross-disciplinary research. Interdisciplinary in the UCM is measured through the collaboration of authors from different institutional addresses within the UCM, both in scientific publications and in research projects. Publications jointly signed by the different teams that collaborate in the projects were identified as an indicator of the success of the Programme in integrating disciplines, hrterdisciplinary collaboration within the UCM showed an upward trend over time. Publications of MRP groups showed a higher interdisciplinary collaboration rate than the rest of the UCM (17% vs.9%). Dramatic repercussions of the Programme were not expected due to its limited magnitude, but it worked as a catalyst, enhancing interdisciplinary relations within the UCM. The interest of such a programme is supported by its effects, both direct effects on granted teams and indirect on the whole UCM community.

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The effects of chlorbutol (0.7, 1.4 and 2.8 mM) on the contractile responses induced by KCl and noradrenaline (NA) and on 45Ca movements have been studied on rat isolated thoracic aorta. Chlorbutol decreased, in a dose-dependent manner, contractions induced by KCl and NA and this effect was observed whether it was added before or after the induced contractions. Preincubation with chlorbutol inhibited the contractile responses elicited by addition of Ca (1-5 mM) to Ca-free high-potassium solution. It also inhibited in a dose-dependent manner the 45Ca influx but increased 45Ca efflux in rat aortic strips. These results suggest that chlorbutol decreases peripheral resistance by reducing the availability of intracellular Ca to the contractile machinery in vascular smooth muscle cells. The effects of synthetic oxytocin (Syntocinon) at concentrations containing the same chlorbutol concentration were quantitatively similar from those produced by chlorbutol alone. Therefore, the inhibitory cardiovascular effects ascribed previously to synthetic oxytocin may be attributed to its preservative, chlorbutol, and not to oxytocin itself.