The study was done to investigate the in vitro anti-diabetic activity of Ethanol-water extract of Abutilon indicum plant leaves. The phytochemicals present in the extract was analyzed by using standard methods. In vitro antioxidant study was done using DPPH radical scavenging activity. The In vitro anti-diabetic studies were done by alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies. The phytochemical analysis showed that the extract rich with proteins, polyphenols, flavonoids, alkaloids, tannins, polysaccharides. The in vitro antiglycation potential of extract was confirmed through alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies. The results of the present study showed the significant antioxidant and antidiabetic activity. The potential pharmacological activity of Abutilon indicum might be the presence of phytochemicals.
DNA of live cells is damaged when exposed to harmful Ultraviolet rays. If the cells are exposed to UV rays exposure time more duration of time, more thymine dimers are formed in the DNA and the greater the risk of an incorrect repair or a missed dimer. To analyze the effect of UV rays Calf thymus DNA and prevention by polyphenol enriched extract of Mint leaves and also its non toxic nature. The above study was done by using submarine gel electrophoresis where UV rays are used to damage the DNA and BHA (400µM) used as positive control. The polyphenol enriched extract was taken at 15μg concentration prevent UV rays induced DNA fragmentation in submarine agarose gel electrophoresis which provides same protection when compared to standard antioxidant BHA (400μM). The cytotoxicity studies showed that, the extract and BHA provides a protection of 54% whereas, the extract of Mint leaves extract showed 72%. In conclusion, the Mint leaves extract showed a promising DNA protectant activity against UV rays induced DNA damage.
Microorganisms are raising resistance against available antibiotics due to usage of antibiotics in a wrong way. There is lot of demand for finding /searching new natural antimicrobial agents as they are inexpensive, easily available, most of them are edible and mainly non-toxic even at the rate of milligram quantity. The aim was to study the efficiency of the anti-bacterial effect of Polyphenols enriched extract of Drum stick plant leaves (Moringa oleifera) against staphylococcus aureus. The materials involved in this study include Drum stick plant leaves, micro-organism staphylococcus aureus in the bacterial type culture collection, agar, and blood-agar plates. At 10% concentration, of Polyphenols enriched extract of Drum stick leaves had zero anti-bacterial activity, while between 20 to 25% concentrations revealed high activity against the bacteria. Thus, increased in the anti-bacterial activity was promising as the concentration augmented from 20 to 25%. The results acquired from this study points that polyphenol enriched extract of Drum stick leaves (Moringa oleifera) had antibacterial property against Staphylococcus aureus when obtained to a necessary concentration.
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