A simple, cost effective and environmentally benign method is reported for the preparation of N,N-dimethylamides from carboxylic acids. The versatility of the method is determined by synthesising a large number of N,N-dimethylamide derivatives. Carboxylic acids are heated at 160-165 °C in N,N-dimethylacetamide solvent in the presence of 1,1′-carbonyldiimidazole to afford the corresponding N,N-dimethylamides in good to excellent yields.
bonyldiimidazole. -The acetylation agent (I) also acts as solvent. The acetylation of primary and secondary amines gives similar results under microwave irradiation compared to conventional heating conditions. -(CHIKKULAPALLI, A.; AAVULA, S. K.; RIFAHATH, M. N. P.; KARTHIKEYAN, C.; VINODH KUMAR, C. H.; MANJUNATHA, S. G.; SHANMUGAM*, S.; Tetrahedron Lett. 56 (2015) 24, 3799-3803, http://dx.
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