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Purpose-To describe the frequencies of and risk factors for ocular complications and poor visual acuity at presentation in a cohort of patients with juvenile idiopathic arthritis (JIA)-associated uveitis.Design-Cross-sectional study.Setting Single-center, academic practice. Procedures Data on patients diagnosed with JIA-associated uveitis were entered retrospectively into a database and analyzed. Study populationOutcome measures Visual acuity of 20/50 or worse or 20/200 or worse, and presence of ocular complications (including cataract, posterior synechiae, band keratopathy, elevated intraocular pressure, hypotony, macular edema, and epiretinal membrane) at presentation.Results-At presentation, ocular complications were seen in 67% of eyes affected by JIAassociated uveitis. Presence of ≥ 1+ anterior chamber flare, a positive antinuclear antibody, and a shorter duration between the diagnosis of arthritis and uveitis were significantly associated with the presence of ocular complication. The frequencies of 20/50 or worse and of 20/200 or worse visual acuities at presentation in affected eyes were 36% and 24%, respectively. The presence of ≥ 1+ anterior chamber flare and a history of intraocular surgery prior to presentation were significantly associated with 20/50 or worse and 20/200 or worse vision. Presence of posterior synechiae also was associated with 20/200 or worse vision at presentation. The main causes of poor vision at presentation for affected eyes and better-seeing eyes were cataract, band keratopathy within the visual axis, and glaucoma.Conclusions-Ocular complications and poor vision at presentation were common in our patients with JIA-related uveitis.

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Purpose-To determine the incidence of cystoid macular edema (CME) after cataract surgery among eyes with and without uveitis using optical coherence tomography (OCT) and to determine risk factors for post-operative CME among eyes with uveitis. Design-Prospective comparative cohort study.Methods-Single-center, academic practice. Forty-one eyes with and 52 without uveitis underwent clinical examination and OCT testing within 4 weeks before cataract surgery and at 1-month and 3-month post-operative visits. Main outcome was incidence of CME at 1 and 3 months after surgery.Results-Both uveitic and control eyes gained approximately 3 lines of vision (P = 0.6). Incidence of CME at 1 month was 12% (5 eyes) for uveitis and 4% (2 eyes) for controls (P = 0.2). Incidence of CME at 3 months was 8% (3 eyes) for uveitis and 0 % for eyes without uveitis (P = 0.08). Eyes with uveitis treated with peri-operative oral corticosteroids had a 7-fold reduction in post-operative CME (relative risk [RR] = 0.14, P = 0.05). In uveitic eyes, active inflammation within 3 months before surgery increased the risk of CME when compared to eyes without inflammation (RR=6.19, P = 0.04). CME was significantly associated with poorer vision (P = 0.01). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptAm J Ophthalmol. Author manuscript; available in PMC 2010 July 1. Conclusions-Eyes with well-controlled uveitis may obtain similar outcomes to control eyes after cataract surgery (up to 3 months). Use of peri-operative oral corticosteroids and control of uveitis for ≥ 3 months before surgery appeared to decrease the risk of post-operative CME among uveitic eyes in this study.

A > or =40% increase in baseline CPT, determined by OCT, offers a valid and objective method of reporting clinically relevant postcataract ME. Standardized reporting of postcataract ME would allow objective assessment and comparison of treatment outcomes among clinical studies.

PIC and MFCPU appeared to have different clinical characteristics at presentation. Patients with PIC had a higher frequency of CNV at presentation but lower frequencies of structural complications from intraocular inflammation and a lower frequency of visual impairment at presentation.

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