A multicenter, randomized, double-blind trial was carried out to evaluate the efficacy of gabexate mesylate (FOY) in acute pancreatitis. One hundred unselected patients were randomly allocated into two groups: 51 were assigned to receive FOY (12 mg/kg/day as continuous intravenous infusion for a minimum of 4 days and a maximum of 12 days), and 49 were allocated to placebo. The groups were comparable in demographic, clinical and biochemical parameters, etiology of pancreatitis, and disease severity, which was gererally mild. Gallstones were the main etiological factor. All patients received fluid and electrolyte replacement, analgesia and nasogastric suction for at least 48 h after admission. Experimental therapy was initiated no later than 12 h after the beginning of symptoms. The results showed no statistically significant differences between the two groups with respect to the evolution of clinical and biochemical parameters, analgesic requirements, development of complications, hospitalization time or mortality at completion of the trial. In conclusion, early treatment with FOY does not appear to have any demonstrable beneficial effects in acute pancreatitis.
Digital printing is nowadays widely used for decorating ceramic products. Noble metal-free, metal-like, tile decoration was developed in the first decade of the 21st century. These glazes are still used in traditional applications, mainly by the bell/waterfall method, which requires application of a large amount of glaze per unit surface area (200-300 g/m 2 ) for the above effect to develop appropriately. Studies 1-6 indicate that, in these glazes, which have a high phosphorus and iron content, during fast firing of the tiles in a typical single-firing process, surface crystallization occurs of iron phosphates, mixed alkali and alkaline-earth phosphates, and hematite nanocrystals, which together determine the surface appearance of the fired coating.As digital printing hardly allows such large amounts of glaze to be applied as those required to obtain the metallic effect, Color Esmalt, S.A., has developed and patented a method for obtaining a metallic effect on ceramic bases by inkjet printing. 7 The method yields a metallic effect by a superimposed application of glaze and ink with an appropriate chemical composition. The set of oxides required to obtain the metallic gloss is distributed between both applications: the iron oxide is introduced in the ink, whereas the other oxides make up the glaze on to which the ink is applied. AbstractInkjet technology has become very popular in recent years and is nowadays widely used for decorating ceramic products. This has led to in-depth study of the operating principles and process variables involved. These notably influence the properties of the deposited ink layers, as do the physicochemical properties of the applied inks and of the glazes on which the inks are deposited. The problems associated with
Pancreatitis after pancreatic EUS-FNA occurs in 2 % of patients, with some more cases of silent hyperamylasemia. This complication may have to be included in the information given to patients for their informed consent.
Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes and determine whether the initial symptomatology can predict long-term cognitive problems. Cognitive evaluations were performed on 109 healthy controls and 319 post-COVID individuals categorized into three groups according to the WHO clinical progression scale: severe-critical (n = 77), moderate-hospitalized (n = 73), and outpatients (n = 169). Principal component analysis was used to identify factors associated with symptoms in the acute-phase and cognitive domains. Analyses of variance and regression linear models were used to study intergroup differences and the relationship between initial symptomatology and long-term cognitive problems. The severe-critical group performed significantly worse than the control group in general cognition (Montreal Cognitive Assessment), executive function (Digit symbol, Trail Making Test B, phonetic fluency), and social cognition (Reading the Mind in the Eyes test). Five components of symptoms emerged from the principal component analysis: the “Neurologic/Pain/Dermatologic” “Digestive/Headache”, “Respiratory/Fever/Fatigue/Psychiatric” and “Smell/ Taste” components were predictors of Montreal Cognitive Assessment scores; the “Neurologic/Pain/Dermatologic” component predicted attention and working memory; the “Neurologic/Pain/Dermatologic” and “Respiratory/Fever/Fatigue/Psychiatric” components predicted verbal memory, and the “Respiratory/Fever/Fatigue/Psychiatric,” “Neurologic/Pain/Dermatologic,” and “Digestive/Headache” components predicted executive function. Patients with severe COVID-19 exhibited persistent deficits in executive function. Several initial symptoms were predictors of long-term sequelae, indicating the role of systemic inflammation and neuroinflammation in the acute-phase symptoms of COVID-19.” Study Registration: www.ClinicalTrials.gov, identifier NCT05307549 and NCT05307575.
Objetivo: O objetivo deste trabalho foi avaliar o impacto de custo total do tratamento de câncer de próstata com metástase óssea na perspectiva do Sistema de Saúde Suplementar (SSS) brasileiro. Métodos: Trata-se de um estudo retrospectivo de coorte conduzido de um banco de dados administrativos fornecidos pela empresa Orizon. A população consistiu em pacientes com registro de câncer de próstata com metástases ósseas, ou procedimentos relacionados, que foram registrados em entradas hospitalares ou ambulatoriais e receberam pelo menos um tipo de tratamento. A perspectiva da análise foi o SSS e o horizonte temporal, uma mediana de 181 dias. O desfecho primário foi o custo global, no qual foram contemplados gastos com exames, procedimentos, materiais e medicamentos. A partir do desfecho primário, foram calculados o custo por paciente, o número de atendimentos por paciente e o custo por atendimento. Adicionalmente foram analisados os custos relacionados aos diferentes subgrupos de tratamentos destinados à doença. Resultados: O custo global relacionado aos atendimentos foi de R$ 21.391.034 (n = 181), o custo médio resultou em R$ 118.183 por paciente, com média de 10,48 atendimentos por paciente e R$ 11.282 por atendimento. Pela análise isolada dos cenários, os custos nos ambientes hospitalar (R$ 11.452.496) e ambulatorial (R$ 9.938.537) demonstraram que houve mais gastos relacionados aos procedimentos hospitalares. Conclusões: O estudo demonstrou elevado impacto econômico de tratamento de câncer de próstata com metástases ósseas no SSS, devido principalmente a maior necessidade de quantidade de hospitalizações com mais tempo de permanência.
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