Background: Sepsis still remains an important cause of morbidity and mortality posing a diagnostic challenge to clinicians across the globe. Lack of a single specific and sensitive test paved the way to many researches. Our study evaluated clinical significance of cell population data (CPD) as biomarkers in sepsis. CPD assesses morphological and functional characteristics of leucocytes using automated hematology analyzer. Methods:The study population consisted of 100 healthy subjects and 100 clinically suspected cases of sepsis with quick sequential organ failure assessment (qSOFA) score >2. The various cell population data (CPD) were collected using automated hematology analyzer, Sysmex XN1000 during a span of 6 months from January to June 2018 in a tertiary care center and the results were statistically analyzed using Z test. Result:The WBC count and CPD parameters were assessed. Except for neutrophil , monocyte cell size (NE-FSC, MO-Z) and lymphocyte fluorescence intensity(LY-Y) all other CPD parameters show significant difference (p<0.001) in sepsis group compared to healthy controls. Conclusion:This study suggested utility of CPD parameters which provide details of size and internal structure of leucocytes to be considered as an important biomarker for diagnosis and management of sepsis.
Nucleated red blood cells are immediate precursors of mature erythrocytes and are less deformable to pass through fenestrations in endothelial lining of bone marrow. Therefore, its presence in circulation i.e. normoblastemia after the neonatal period is considered abnormal and needs further evaluation. [1,2,4] Materials and MethodsThis retrospective study was conducted in a tertiary care centre. The study period was 3months, i.e. from February 2018 to April 2018. The presence of nRBCs in the peripheral blood was detected with the help of automated analyzer (Sysmex XN 1000) and by laboratory data retrieving. Peripheral smear correlation was done. It was followed by tabulation and analysis of results. Among the patients of age ( 15-25years ), the causes were microcytic hypochromic anemia ± neutrophilia (n=10), thrombocytopenia (n=1), eosinophilia (n=1) and pancytopenia (n=1). The count ranged from 0.1-1.5 nRBCs/100WBC.In patients of >25years of age, a total of (n=40) cases were microcytic hypochromic anemia, (n=24) were normocytic
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