Background: Newborn screening programs signify early and presymptomatic detection of treatable disorders which authorize commencement of prompt medication to alleviate notable fatality. Newborn screening (NBS) for congenital hypothyroidism (CH) has been a successful public health initiative in preventive medicine over the last few decades. Previous pilot (1999-2006) and phase 1 (2006-2011) NBS program in Bangladesh reported an increased incidence compared to global data which urged to initiate a second phase NBS program for the detection of CH.
Materials & Methods: Neonates’ blood was collected from the umbilical cord or by heel prick and drawn on the Guthrie filter paper card. Thyroid-stimulating hormone (TSH) was measured from this filter paper by Immunoradiometric assay (IRMA) or Dissociation Enhanced Lanthanide Fluorescence Immunoassay (DELFIA) method.
Results: 123 out of 2,61,550 neonates have already been diagnosed with congenital hypothyroidism from September 2018 to August 2020, which represents an incidence of 1:2126.
Conclusion: Ongoing phase-2 project data is already showing some optimistic outcomes. Hence, a time-worthy sustainable policy should be implemented to mark this program as an effective one.
Bangladesh J. Nuclear Med. 25(1): 15-21, 2022
PET-CT (positron emission tomography and computed tomography) is a gold-standard cancer imaging tool for diagnosis and management, as well as prognostic information based on treatment. Positron-emitting radionuclide 18F (Fluorine) is generated by accelerating particles to energies high enough to cause a certain nuclear reaction 18O(p,n)18F within the particle accelerator, the cyclotron. Mannose triflate is converted to 2-[18F] Fluoro-2-deox-D-yglucose ([18F]FDG) via nucleophilic reaction. Under the ownership of Bangladesh Atomic Energy Commission installed a medium energy (18/9 MeV, IBA) Cyclotron at National Institute of Nuclear Medicine and Allied Sciences (NINMAS). The facility was established in the oncology Building (Block F) of Bangabandhu Sheikh Mujib Medical University (BSMMU). Cyclotron vault and the Control room are located in the underground i.e. basement floor. Each wall of the cyclotron vault and ceiling is made of concrete with a density of 2.35 g/cm3 and a thickness sufficient to shield gamma and neutron radiation. On the ground floor, there are Synthesis room, Quality control laboratory, and the Decontamination room. PET-CT rooms are located on the first floor. Identification, Radionuclide purity (Gamma spectrum detection and half-life measurement), Radiochemical Purity, Chemical purity, Residual solvent measurement, pH measurement, Sterility, and bacterial endotoxins (LAL test) are performed to maintain the quality of the product. The current uses of the Cyclotron are mostly for the synthesis of 18F-FDG.
Bangladesh J. Nuclear Med. 24(1&2): 48-50, 2021
2-[18F]Fluoro-2-Deoxy-D-Glucose ([18F]FDG) is very effective and the most successful radiotracer for the assessment of glucose metabolism in the brain, heart, and lungs. It has also been used for imaging different tumors in oncology. The purpose of this study was to evaluate the stability and quality of [18F]FDG synthesized by the newly installed 18MeV Cyclotron facility at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS). [18F]FDG was synthesized by nucleophilic fluorination of Mannose-triflate followed by basic hydrolysis with an IBA Synthera® auto synthesizer. [18F]FDG solution was collected in a sterilized vial after the filtration by a vented Millex®-GS 0.22µm syringe-driven hydrophilic filter. An aliquot of [18F]FDG solution was taken 0, 2, 4, 6, and 8 hours after the synthesis. All quality control parameters were measured in the first evaluated period, immediately (i.e., 0 hours) after synthesis. Radiochemical purity (RCP) was measured for all [18F]FDG samples and for all time points. The radiochemical and radionuclidic purity was more than 95% and 99.99% respectively. The [18F]FDG was physiochemically & microbiologically stable over 8 hours.
Bangladesh J. Nuclear Med. 26(1): 44-50, 2023
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