Multiple myeloma (MM) is a clonal proliferation of malignant plasma cells mainly affecting the bone marrow. Most common sites of extramedullary dissemination reported in the literature are skin, liver, kidneys and central nervous system. The presentation of MM with lung plasmacytoma is found to be very uncommon. We present a case of multiple myeloma associated with lung plasmacytoma. A 53-years-old man with history of shortness of breath and lung opacity visualized on a chest X-ray. Careful integration of clinical manifestations with radiological and biological data led to the diagnosis of multiple myeloma with pulmonary plasmacytoma.
Study objectives: This study attempts to describe the epidemiological and biological profiles as well as the common etiologies of thrombocytopenia in patients admitted to University Hospital center Mohammed VI in Marrakesh, Morocco, over a period of six months between March 2021 and August 2021. Patients and methods: This is a prospective study of 673 patients hospitalized in the University Hospital center -Mohammed VI-Marrakesh between March and August 2021 whose admission blood tests show thrombocytopenia. Results: Thrombocytopenia was found in 673 patients, mainly from the intensive care unit (28%) and the department of hematology & oncology (16%), the sex ratio was 1.3 with a male predominance of 58%, the average age of our patients was 37.1 years. On biological plan, prothrombin (PT) and CRP were the two most noticed disturbed biological markers in our series, at 50% and 79% respectively, the etiological profile of our patients demonstrated a predominance of peripheral thrombocytopenia at 83.2%, The most frequent causes were infectious (43%), bacterial, viral or parasitic, followed by anomaly of distribution of platets (12%) and immunological thrombocytopenia (9%). Conclusion: Our study shows that thrombocytopenia is a frequent biological anomaly that can affect both sexes, of any age, it is most often multifactorial, but the main cause is infection, requiring a correlation of epidemiological, clinical and biological profiles in order to adapt the treatment.
Bilateral proliferative retinopathy is a rare complication of chronic myeloid leukemia (CML) as a few case reports have been published to date. In this case report, a 32-year old diabetic female presented with history of bilaterally decreased vision. Ophthalmologic examination showed bilateral proliferative retinopathy (i.e., retinal detachment, vitreous hemorrhage, pre-retinal fibrosis and the presence of bilateral peripheral capillary dropout with multiple retinal sea fan neovascularization) for which panretinal laser photocoagulation and vitrectomy were planned. During the preoperative workup, complete blood count revealed hyperleukocytosis. Later on, the karyotype analysis identified Philadelphia chromosome, confirming the diagnosis of CML. Hence, it was an interesting case where bilateral proliferative retinopathy directed to the diagnosis of CML. Therefore, proliferative retinopathy may be the first presentation of CML.
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