Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndrome. Therefore, prevention of cardiac hypertrophy and failure would be one goal to reduce broiler ascites syndrome incidence. Myocardial hypertrophy and failure are closely related to endoplasmic reticulum stress (ERS) in cardiac myocytes, and the endoplasmic reticulum stress signaling system (ATF6-DR5) is one of the important pathways of myocardial apoptosis. Excessive hypertrophy will affect the heart muscle’s normal contraction and diastole function, and the heart will turn from compensated to decompensate thus causing myocardial injury. Myocardial apoptosis is a core component of the pathological changes of this myocardial injury. Nano-selenium is a kind of red elemental selenium nanoparticle. Due to its excellent physical, chemical and biological properties, it has attracted extensive academic attention in recent years. It has been proven to have excellent antioxidant, antibacterial, antitumor, antihypertrophic, and antiapoptotic abilities. Herein, nano-selenium (1 µmol/L) can inhibit hydrogen peroxide (H2O2)-induced oxidative stress in broiler primary cardiomyocytes, and at the same time reduce cardiomyocyte apoptosis. In vivo, nano-selenium can reduce broiler myocardial injury-related enzyme indicators (AST, CK and LDH), and alleviate myocardial injury. It can also activate the antioxidant enzyme system (SOD, GSH-Px and CAT) and reduce MDA, and make the recovery of T-AOC ability in the organization. Meanwhile, nano-selenium can down-regulate the genes and proteins expression of ATF-6, GRP-78, CHOP and caspase 12 in the ERS-related signaling pathway, and inhibit that of downstream-related caspase 3, Bax and caspase 9, and increase that of the downstream anti-apoptotic Bcl-2, thereby maintaining the homeostasis of the endoplasmic reticulum and alleviating cardiomyocyte apoptosis. It can be seen that nano-selenium can protect the damaged myocardium in the broiler ascites caused by high-salt drinking by regulating the ATF6-DR5 signaling pathway. This study was performed in chickens and cardiomyocyte cells and attempted to demonstrate that selenium nanoparticles can protect the damaged myocardium in broiler ascites. This paper provides a new idea for preventing and treating broiler ascites syndrome.
Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well-documented that Myocardial hypertrophy and failure is one of the critical mechanisms in broiler ascites syndrome, and preventing cardiac hypertrophy and failure to cardioprotection may be one of the targets for lowering the incidence of broiler ascites syndrome. Nano-selenium has received a lot of attention in the biomedical field in recent years due to its unique physicochemical properties and potential applications in drug development and targeted therapy. The antioxidant capabilities of nano-selenium have been demonstrated to inhibit apoptosis. To investigate the impact of nano-selenium on broiler chicken heart injury caused by broiler ascites syndrome, we created a broiler chicken cardiomyocyte apoptosis model and a broiler chicken ascites syndrome model. Pretreatment of broiler cardiomyocytes with nano-selenium reduced oxidative stress and apoptosis caused by hydrogen peroxide, according to our findings. Furthermore, nano-selenium supplementation with broiler chickens' diets that inactivated the endoplasmic reticulum stress signaling system (ATF6-DR5). The current study sought to demonstrate that nano-selenium protects injured myocardium in a broiler ascites model, and the proposed mechanism is linked to the ATF6-DR5 signaling pathway, opening up new avenues for medication development to prevent and treat broiler ascites disease.
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