Selenium nanoparticles reduce cardiomyocyte apoptosis in Ascites Syndrome in Broiler Chickens via the ATF6-DR5 signaling pathway

Abstract

Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well-documented that Myocardial hypertrophy and failure is one of the critical mechanisms in broiler ascites syndrome, and preventing cardiac hypertrophy and failure to cardioprotection may be one of the targets for lowering the incidence of broiler ascites syndrome. Nano-selenium has received a lot of attention in the biomedical field in recent years due to its unique physicochemical properties and potential applications in drug development and targeted therapy. The antioxidant capabilities of nano-selenium have been demonstrated to inhibit apoptosis. To investigate the impact of nano-selenium on broiler chicken heart injury caused by broiler ascites syndrome, we created a broiler chicken cardiomyocyte apoptosis model and a broiler chicken ascites syndrome model. Pretreatment of broiler cardiomyocytes with nano-selenium reduced oxidative stress and apoptosis caused by hydrogen peroxide, according to our findings. Furthermore, nano-selenium supplementation with broiler chickens' diets that inactivated the endoplasmic reticulum stress signaling system (ATF6-DR5). The current study sought to demonstrate that nano-selenium protects injured myocardium in a broiler ascites model, and the proposed mechanism is linked to the ATF6-DR5 signaling pathway, opening up new avenues for medication development to prevent and treat broiler ascites disease.