In this research we conducted a comparative study of immune responsive traits for the two exotic chicken breeds viz. Australorp and Cornish with one of the indigenous Kadaknath chicken breeds. Immune response to Sheep Red Blood Cells (SRBC) was measured in terms of Haemagglutination Titre (HA) and Haemagglutination Inhibition titre (HI) at five stages viz; 0 (pre inoculation), 3 rd , 6 th , 9 th and 12 th days post primary inoculation (PPI) of SRBC. The HA titre was significantly (P<0.05) higher in the native breed Kadaknath at all the five stages. The in-vivo cell mediated response to mitogen phytohaemagglutinin was higher in Kadaknath chicken as compared to exotic chicken. The native Kadaknath breed has stood out over Australorp and Cornish for generation of humoral and cell mediate immune response and it indicates that the indigenous breeds have considerable potential to reduce susceptibility to infectious diseases.
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