PurposeTo evaluate and compare the mechanical properties (flexural strength and surface hardness) of different materials and technologies for denture base fabrication. The study emphasized the digital technologies of computer‐aided design/computer‐aided manufacturing (CAD/CAM) and three‐dimensional (3D) printing.Materials and MethodsA total of 160 rectangular specimens were fabricated from three conventional heat‐polymerized (ProBase Hot, Paladon 65, and Interacryl Hot), three CAD/CAM produced (IvoBase CAD, Interdent CC disc PMMA, and Polident CAD/CAM disc), one 3D‐printed (NextDent Base), and one polyamide material (Vertex ThermoSens) for denture base fabrication. The flexural strength test was the three‐point flexure test, while hardness testing was conducted using the Brinell method. The data were analyzed using descriptive and analytical statistics (α = 0.05).ResultsDuring flexural testing, the IvoBase CAD and Vertex ThermoSens specimens did not fracture during loading. The flexural strength values of the other groups ranged from 71.7 ± 7.4 MPa to 111.9 ± 4.3 MPa. The surface hardness values ranged from 67.13 ± 10.64 MPa to 145.66 ± 2.22 MPa. There were significant differences between the tested materials for both flexural strength and surface hardness. There were also differences between some materials with the same polymerization type. CAD/CAM and polyamide materials had the highest flexural strength values. Two groups of CAD/CAM materials had the highest surface hardness values, while a third, along with the polyamide material, had the lowest. The 3D‐printed materials had the lowest flexural strength values.ConclusionsGenerally, CAD/CAM materials show better mechanical properties than heat‐polymerized and 3D‐printed acrylics do. Nevertheless, a material's polymerization type is no guarantee of its optimal mechanical properties.

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New onset pediatric CD is characterized by Th1 response in ileum and mixed Th1/Th17 response in the colon, with elevated expressions of innate IL-6 and IL-1β. SOCS1/SOCS3 expressions seem to be insufficient for the regulation of the immune response. The reduction in MDR1 expression points to its role in the disease pathogenesis. What is Known: • CD is characterized by an aberrant immune response What is New: • The immune response in new onset pediatric CD differs between terminal ileum and colon • MDR1 expression is downregulated at both terminal ileum and colon irrespective of the disease activity.