Evaluation of victims of neurotoxic snake bite for early signs of respiratory depression and prompt respiratory assistance, even if anti-venom is not available, is most essential as a life saving measure.
Globally, the area of angiogenesis is dominated by investigations on anti-angiogenic agents and processes, due to its role in metastatic cancer treatment. Although, the area of ischemic tissue reperfusion is having much bigger demand and foot-mark. Following clinical failure of VEGF (Vascular endothelial growth factor) as a potential agent for induction of a controlled angiogenic response in ischemic tissues and organs, the progress is reasonably quiet as for new low molecular weight (LMW) angiogen molecules and their clinical applications are concerned.Basic amino acid Lysine has been observed to have profound angiogenic property in ischemic tissues, which is controlled, reproducible, time bound and without any accompanying reperfusion damage. In this study, the basic amino acid Lysine has been suggested as a LMW-angiogen, where it has been proposed to have a molecular binding property between VEGF and VEGF receptor (VEGFR). Here, the molecular adhesive hypothesis is being probed and confirmed both in the clinical and lab conditions through induced angiogenic response in tissue repair and in chick chorio allantoic membrane (CAM), respectively; and in dry-docking experiments (in-silico studies).
SUMMARYThe tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal, India, was extensively screened for pharmacological and biochemical properties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes (both direct and indirect), produced haemorrhagic lesions in the skin and also released haemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to produce pro-inflammatory effects when injected into the rat hind paw and also increased peritoneal vascular permeability. Furthermore, intravenous administration of TTE produced a decrease in blood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esterase activity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro). TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and protease activities.
Herein, a novel and comprehensible approach has been
suggested to degrade the emerging micropollutants such as synthetic dyes. In
this study, a continuous UV-C irradiation has been used to treat the aqueous
matrix of synthetic pollutant dyes under highly alkaline environment (pH
>13.0). In this HA-AOP, the treatment rate and degradation efficiency are
primarily found to be affected by the type of pollutant dye present in the
matrix, concentration of XOH or pH and UV-C fluence rate. In addition, the
kinetic study indicates that HA-AOP or UV-C/XOH(X=Na or K) process follows zero
order reaction kinetics during the degradation of parent pollutant species. The
explored approach is quite auspicious due to its tremendous potential to handle
versatile aqueous matrices containing natural organic materials, inorganic
salts, fatty matters, surfactants and many more things. Overall, unlike other
AOPs, this novel UV-C/XOH(X=Na or K) based HA-AOP could be highly utilized for
the effective treatment of various alkaline wastewater streams.
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