Pharmacological and Biochemical studies on Telescopium telescopium - a marine mollusk from the Mangrove regions

Abstract

SUMMARYThe tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal, India, was extensively screened for pharmacological and biochemical properties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes (both direct and indirect), produced haemorrhagic lesions in the skin and also released haemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to produce pro-inflammatory effects when injected into the rat hind paw and also increased peritoneal vascular permeability. Furthermore, intravenous administration of TTE produced a decrease in blood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esterase activity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro). TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and protease activities.

Arylamine N-acetyl Transferase (NAT) in the blue secretion of Telescopium telescopium: xenobiotic metabolizing enzyme as a biomarker for detection of environmental pollution

“…Secretions from the mollusks (around 15) were pooled in a sterile container. An aliquot of pooled sample was defatted using dichloromethane (DCM) (Samanta et al 2008b ) for protein fractionation (discussed below).…”

“…Accordingly, investigations were taken up in our laboratory for evaluation of pharmacological and biochemical properties of Telescopium telescopium (tissue extract and blue secretion). Earlier studies revealed neuro-pharmacological (Samanta et al 2008a ) haemolytic, pro-inflammatory and hypotensive properties (Samanta et al 2008b ) of tissue extract of Telescopium telescopium. The pharmacological and antimicrobial properties of spermathecal gland of Telescopium telescopium has also been reported (Datta et al 2010 ; Pakrashi et al 1992 ; Pakrashi et al 2001 ).…”