Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box–Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM -loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds.

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High mortality and morbidity rates are related to hepatocellular carcinoma (HCC), which is the most prevalent type of liver cancer. A new vision for cancer treatment and cancer cell targeting has emerged with the application of nanotechnology, which reduces the systemic toxicity and adverse effects of chemotherapy medications while increasing their effectiveness. It was the goal of the proposed work to create and investigate an anticancer C@Fe@Cu nanocomposite (NC) loaded with Doxorubicin (DOX) for the treatment of HCC. Scanning and transmission electron microscopes (SEM and TEM) were used to examine the morphology of the produced NC. The formulation variables (DOX content, C@Fe@Cu NC weight, and stirring speed) were analyzed and optimized using Box-Behnken Design (BBD) and Response Surface Methodology (RSM). Additionally, X-ray diffraction patterns (XRD) and Fourier Transform Infrared (FTIR) were investigated. Doxorubicin and DOX- loaded C@Fe@Cu NC (DOX-C@Fe@Cu NC) were also assessed against HEPG2 cells for anticancer efficacy (Hepatic cancer cell line). The results revealed the formation of C@Fe@Cu NC with a mean size of 7.8 nm. A D-R model with a mean size of 24.1 nm best fits the adsorption behavior of DOX onto the C@Fe@Cu NC surface. DOX-C@Fe@Cu NC has also been demonstrated to have a considerably lower IC50 and higher cytotoxicity than DOX alone in an in vitro investigation. Therefore, DOX-C@Fe@Cu NC is a promising DOX delivery vehicle for the full recovery of HCC.

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The effects of plasma surface engineering on average surface roughness, wettability and gamma ray attenuation properties of AISI316L standard steel sample were investigated. The results showed an increase in surface roughness accompanied with an increase in the surface energy and a decrease in the contact angle of the N316L sample treated by plasma carbonitriding. The experimental measurements of gamma ray attenuation properties of the investigated stainless-steel alloys were carried out using gamma lines emitted from 232 Th and 60 Co gamma ray sources. The attenuation parameters such as linear and mass attenuation coefficients and half value layer were determined experimentally and theoretically. The obtained results indicate that the rf plasma surface treatment is an effective method for developing the surface tribological properties of the treated stainless-steel alloy without any change in the gamma ray attenuation properties. The obtained results suggest the suitability of N316L for in-core applications of nuclear reactor systems.

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The current paper investigates the effect of the heat treatment process on three grades of stainless steel alloys against the abrasive and the lubricant wear conditions, using 25 wt.% glucose solution for the industrial agriculture applications. The heat treatment process was carried out for one hour at 900 ± 10 °C, followed by quenching with monograde motor oil and tempering for more than two hours at 200 ± 10 °C. Several analyses were conducted to estimate the final mechanical, surface morphological and tribological properties for the studied materials, before and after the heat treatment process. The heat-treated martensitic stainless steel grade exhibited superior wear resistance and higher hydrophobicity compared to the other two heat-treated austenite stainless steel grades. Therefore, the mechanism of the heat treatment process, the chemical and physical nature of the parent material, and the viscosity of the selected lubricant all influence the final behaviour of the studied material against the applied operating conditions for the selected application.