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Introduction Hyperandrogenism produces change in quality of life of women. Aim To prespectively determine the changes of the sexual behaviour of hyperandrogenic women using an oral contraceptive containing 30 µg ethinylestradiol and 2 mg chlormadinone acetate (EE/CMA). Methods Seventy-two volunteer women (age range, 18–32 years), with moderate to severe hirsutim and acne were treated with EE/CMA for 9 cycles. Main Outcomes Measure(s) To assess hirsutism, the Ferriman-Gallwey (F-G) scoring system was used. Serum FSH, LH, estradiol, total and free testosterone, DHEAS, androstenedione, and SHBG levels were measured at baseline and at the 9th cycle of pill intake. The Short Personal Experience Questionnaire (SPEQ), the Short Form-36 (SF-36), and a visual analog scales questionnaires were used to assess the QoL, at baseline and after 3, 6 and 9 cycles of pill use. Result(s) A reduction of 65% and 81% in the total mean F-G score was observed after the 6th cycle and the 9th cycle, respectively. The serum Androstenedione, and total and free testosterone levels decreased, and SHBG levels increased after the 9th cycle (p < 0.05). The SF-36 score was higher after 6 (p < 0.05) 9 cycles (p < 0.001) with respect to baseline. Frequency of sexual intercourse and of orgasm by intercourse increased, and the frequency of masturbation decreased during the 6th (p < 0.05) and the 9th cycle (p < 0.001). Conclusion(s) The EE/CMA pill has anti-androgenic properties reducing the anti-aesthetic effect of hyperandrogenism and improving female sexual and social self-esteem.

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ABR seems to depend on the variations of ovarian steroids during the menstrual cycle and during oral contraceptive intake.

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Departments OF Hmtbld Anatomy. O b r t c t r i c r and Gynmcology 11".and P e d i a t r i c s . U n l v e r a i c y ot h t a n l a , Cmtmnla, t t r l g . M a t r r n a l and l e t m l serum i n~u l i n r t s p o n s r t o g l u t o~~. ImucIno and l e u c i n e p l u s glucose uma oxamtncd by I n f u a l o n e t o n a t w l prcg,runt -m e n a t term l m cd l a r @ I r b e f o r e calmrean r e c t l o n . The ~t a m . 1 Lnfumlon o i s l u c o s t (M 8 ) f o r 30 m r 60 minutes vaa asmocinted w i t h rmrkad hypaqlycomi. m d u l t h n r l t e I n r e r v a I n m u l i n i n m t k e r and f~t u . . Thm f e r a l Lnawlln reaponme t o t h e admin l s t r a t l o n o f g1uto.c f o r 60 minutea was h i g h e r Ip+O.OlS t h a n when the maat dose war g l v r n t o r 30 minutes. u h l l m r h e b l o o d g l u c n r e urns Lorsr (14 0.01).The m a t e r n a l i e t u s i o n o t a r m l l e r dose o f glucose 125 g ) et Leuclne 0 5 g) t o r 40 minute# productd an increane ill sti n r u 1 L n o n l y ln t h e w r h e r s .Houever the almultanrous ~d n i n i s t r * t t o n o f these aubrtanccs s t i m u l a t e d r u r c rn a l and f e t a l L n a u l i n accretion. Tha f e t a l l n r u l l n l e v a 1 produced war a i m l l~r t o t h n t a c r n a f t e r the n r t e r~l l n f u s i o n o r 50 g ~f glucose t o r f.0 ~i e u t t s .v h l l s t h e c o r d b i o o d ~l u c o r e wan r l l g h t l y h l g h e r b u t m l g n i l i c s n t l q d t t l e r e n t (pd0.01) than r h a r e r s n I n t h e r a l t n c lntuaed group.I t 1 1 swg8aatcd tbt amino mcidr u l t h glucome r t s u l r t e f c t m l L n s u l l n metret i a n .C l u c o s t r a p i d l y c r e r l e a t h c pl#ranrm I n t h e prssenca o l a concentration g r a d l e n t betvcen mthmr and f e t u s and i t has bean s u g e e t t d rhst f e t a l plasma g l u c o r e is c o n t r o l l e d i n d i r e c t l y v i a t h e u t m m m l c n d o c r l n * #yetem (31. Inau-I I n i r preeent I n t h e f e t a l pancreas as e a r l y aa zhe 1 0 t h g c a t s t l o n s l week and i n l t t m l p l u s s Irm t h e 1 2 t h vemk (15. 11. 201. The ImmulIn l a o f i e t m l o r lg i n sinc. t h e hursle plntentm i s e i t h e r I m p e m a b l e o r t h e amount ~r a n a f t r r t di s p h y a i o l~~l c a l l y inmignLficmnt (18). Houauer. l l s t l e I n f o m t i o n i s c v a i l ab l e r c g m r d l n~ t h e development of thm m e f h a n l~n s t h t c o n t r o l I t s s e f r r t l o n by t h e feral bee4 c e l l * o r i t s p h y a i o l g l c a l eftectm. S t u d l e r hauc decmnstrattd t h t e a r l y I n 8c.tation (12 t o 20 wtcka) t e t m l L n r u l t n r t r p o n s a r o u t e r n m l b y p a r g l y c c a l a l a n e g l e g l b l c (15). By t e n t h e l e f u l i n u t e r o 14 cmpable af r e a p o d I n a t o ~t e r n m l hypcrglycemia w i t h a n e l t v a r l o n -I s a r m 1nmulin.though t h e renponaes a r e mttenuatmd coaparrd w l r h chote o f a d u l t 5 (151.Tha o b j e c t o f t h e p r e r s n c ntudy 1s co p r o v i d e evidence t h a t soae anln...

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