Changes in clitoral blood flow in premenopausal women affected by type 1 diabetes after single 100-mg administration of sildenafil

Caruso, Salvatore; Rugolo, Salvatore; Mirabella, Daniela; Intelisano, Giorgia; Mari, Lucia Di; Cianci, Antonio

doi:10.1016/j.urology.2006.01.059

Cited by 46 publications

(34 citation statements)

References 24 publications

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“…The main finding of this meta‐analysis is that sexual dysfunction (FSD) is more frequent in diabetic women than in control women. This greater frequency, however, is not unanimous, being reported in the majority of studies , but not in other studies . The risk for FSD is 2.27 and 2.49 in type 1 and in type 2 diabetes, respectively, and is 2.02 when considering “any diabetes,” that is the two types of diabetes considered together.…”

Section: Discussionmentioning

confidence: 76%

“…Excluded trials were identified with the reason for exclusion (Figure ). Twenty‐six studies met the inclusion criteria , all published as full reports (Table ).…”

Section: Methodsmentioning

confidence: 99%

“…Since the early 1980s, original studies and reviews have reported sexual dysfunction in diabetic women . Sexual dysfunction is currently established on the basis of a Female Sexual Function Index questionnaire (FSFI, ), which explores several domains of sexual life, namely arousal, excitement, satisfaction, lubrication, orgasm, and pain preceding or during the sexual intercourse.…”

Section: Introductionmentioning

confidence: 99%

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Female Sexual Dysfunction and Diabetes: A Systematic Review and Meta-Analysis

Pontiroli

Cortelazzi

Morabito

2013

The Journal of Sexual Medicine

140

102

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Introduction Sexual dysfunction is reported in diabetic women (female sexual dysfunction [FSD]). Aim To examine the frequency of FSD in diabetic women, and its clinical or metabolic correlates, through meta-analysis of available studies. Methods We searched in MEDLINE, EMBASE, Cochrane Library, and in reference lists of articles and systematic reviews; we considered human clinical studies published as full articles reporting on FSD in diabetic and control women. In total, we considered 26 studies, including 3,168 diabetic and 2,823 control women. Main Outcome Measures Frequency of FSD and score of Female Sexual Function Index (FSFI) as a function of study size, patient details (age, body mass index [BMI], duration of diabetes, metabolic control [HbA1c], chronic complications, Beck Depression Inventory [BDI] score). Results Frequency of FSD was higher in type 1 (OR [95%CI] 2.27 [1.23, 4.16]), in type 2 diabetes (2.49 [1.55, 3.99]), and in “any diabetes” (type 1 and 2) women (2.02 [1.49, 2.72]) than in controls for any duration of diabetes. FSFI was lower in type 1 (−0.27 [−0.41, −0.12]), in type 2 diabetes (−0.65 [−0.75, −0.54]), and in “any diabetes” women (−0.80 [−0.88, −0.71]) than in controls. Depression was significantly more frequent in diabetic than in control women. At meta-regression only BMI was significantly associated with effect size (P = 0.005). At weighed regression, the only significant association was found between age and FSFI (P = 0.059). The limitations were as follows: only studies of observational nature were available, and heterogeneity was seen among studies. Conclusions FSD is more frequent in diabetic than in control women, but it is still poorly understood; low FSFI is associated with high BMI. Further studies are necessary to better understand risk factors for FSD in diabetic women.

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Section: Discussionmentioning

confidence: 76%

“…Excluded trials were identified with the reason for exclusion (Figure ). Twenty‐six studies met the inclusion criteria , all published as full reports (Table ).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Female Sexual Dysfunction and Diabetes: A Systematic Review and Meta-Analysis

Pontiroli

Cortelazzi

Morabito

2013

The Journal of Sexual Medicine

140

102

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“…It seems that somatic sensory system is affected by diabetes and intruitos vagina, labium minora and clitoris are the most deteriorated genital sites in diabetic women. Even though manifesting of sexual difficulties is not always expected and medication can improve blood flow in clitoris [11,12]. It is argued that neuropathy, vascular impairment, and psychological complaints are recognized factors in the pathogenesis of female sexual dysfunction in diabetic women [13].…”

Section: Introductionmentioning

confidence: 99%

Sexual dysfunctions in patients with diabetes: a study from Iran

Ziaeirad

Vahdaninia

Montazeri

2010

Reprod Biol Endocrinol

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BackgroundDiabetes mellitus is a chronic disease that causes short and long-term complications. This study aimed to investigate the prevalence of sexual dysfunctions (SD) among diabetic patients in Iran and to examine whether glycemic control has a role in SD.MethodsA consecutive sample of diabetic women and men who were registered in the Isfahan Endocrine and Metabolism Center, Iran were studied. Sexual dysfunction was evaluated using the Female Sexual Function Index (FSFI) in women and the International Index of Erectile Function (IIEF) in men. In addition the level of glycosylated hemoglobin was assessed to classify the diabetes status in patients.ResultsIn all 200 patients (100 male and 100 female) were entered into the study. The mean age of patients was 48.6 (SD = 7.3) years and most had type 2 diabetes (91.0%). The results showed that sexual dysfunctions were widespread in both gender and 165 (82.5%) patients reported that experienced at least one sexual dysfunction. There were significant associations between sexual dysfunctions and gender and type of diabetes (P = 0.04). Women and patients with type 1 diabetes had higher rates of SD. No major differences were found between SD and age, diabetes status, duration of diabetes and hypertension. In addition, glycemic control did not show a significant association with SD in both genders.ConclusionThe findings of this study showed that SD prevalence was high in diabetic patients of both genders and the glycemic control did not correlate with the frequency of SD in the study population. It is recommended that SD should be addressed more precisely in health care practice in Iran.

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“…[34], [35] The important factors among the aetiologies of SD in diabetic women are neuropathies, vascular impairments and psychological discomforts. [36] Sexual health is often a neglected component of health care in diabetics. [37] A study by Wallner regarding sexual functioning among diabetic and non-diabetic women showed that type 2 DM patients experience similar sexual functioning to women without DM, but women with type 1 DM report more sexual dysfunction such as dyspareunia.…”

Section: Discussionmentioning

confidence: 99%