An Ir-catalyzed tandem synthesis of various N-methylated tertiary amines from three-components coupling of carbonyl compounds, amines, and methanol following reductive amination/N-methylation is reported for the first time. A wide array...
The long-established practice of using organic solvents in synthetic chemistry is currently becoming a major focus for environmental alarms as many of the chemical wastes are generated in the form...
An acceptorless dehydrogenative methodology for the synthesis of amides, aldehydes and ketones from hemiaminal and alcohols in the presence of manganese(I) based photocatalyst is developed. Several aromatic, aliphatic, heterocyclic aldehydes and primary aryl amines as well as secondary alkyl amines were coupled, providing the corresponding amides. The methodology was also extended for dehydrogenation of various alcohols to get the corresponding carbonyls. The proposed catalytic cycle was supported by various control experiments as well as different analytical techniques such as NMR, IR and ESI‐MS.
The transformation of ethanol to value-added chemicals has tremendous potential. However, generally, harsh reaction conditions are needed for the functionalization of ethanol due to its high dehydrogenation energy. Herein, a metal-free photo-mediated activation of challenging ethanol and higher aliphatic alcohols for the synthesis of differently functionalized benzimidazoles under mild conditions is disclosed. The interplay of a photocatalyst and a HAT reagent facilitated the activation of aliphatic alcohols. A wide array of diamines with different functional groups were well tolerated, and the protocol was also extended to N-substituted diamines for the synthesis of industrially important benzimidazoles. A probable catalytic cycle was proposed based on various mechanistic studies.
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