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Ten dogs were given mitoxantrone at a dose of 5 mg/m2 body surface area intravenously. Recombinant canine granulocyte colony-stimulating factor (rcG-CSF) was administered subcutaneously daily for 20 days after an infusion of mitoxantrone in five of these dogs to determine the effect of the hematopoietic growth factor on the duration and severity of myelosuppression. The median neutrophil counts dropped below normal (less than 3,000/uL) for 2 days in the dogs that received rcG-CSF, and for 5 days in the dogs that received only mitoxantrone. Four of five dogs not treated with rcG-CSF and none of those receiving rcG-CSF developed serious neutropenia (less than 1,500/uL). The neutrophil counts were significantly (P less than 0.05) higher in the rcG-CSF treated dogs at all time points except before the administration of the colony-stimulating factor, and the sixth day after the mitoxantrone was administered. These findings demonstrate that rcG-CSF is capable of reducing the duration and severity of mitoxantrone-induced myelosuppression.

Concept of research activity and development of fishing technology in the future is not only aimed to improve the catch but is also aimed to improve the capture process, reducing the impact of fishing on the environment and biodiversity. The research was conducted with the purpose of the analysis stage of the operation and problems in operating the lift net (bagan pete pete) typical South Sulawesi especially Barru Regency and inputs to the tactics and methods of fishing, through: analyze stage of the operation and analyze the patterns of fish behavior around lighting on the boat lift net (bagan pete pete) by using LED light. This study was conducted in in Barru District waters, Strait of Makassar, South Sulawesi. Field observations were conducted from June-August 2014 (20 trips). Analysis of the fishing was done descriptively to see the stages of operation, while fish behavior was observed by using fish finder. Stages of operation bagan petepete was preparation operation, heading fishing ground, the lighting process, setting, soaking, the process of extinguishing the lights, hauling, taking the catch, and the process of appointment of waring to the boat. Fish shoal approached the light was at a depth of 5-10 m and 20-30 m from any directions after all the lights turned on. When only one lamp lit on each side, the shoal was getting smaller but in larger density.Keywords: capture process, fish behavior, Light Emitting Diode, lift net ABSTRAKKonsep aktivitas penelitian dan pengembangan teknologi penangkapan ikan pada masa yang akan datang tidak hanya ditujukan meningkatkan hasil tangkapan tetapi juga ditujukan untuk memperbaiki proses penangkapan (capture process), mengurangi fishing impact terhadap lingkungan dan biodiversitas. Penelitian dilakukan dengan tujuan untuk menganalisis tahapan pengoperasian dan permasalahan dalam mengoperasikan lift net (bagan pete pete) khas masyarakat Sulawesi Selatan khususnya Kabupaten Barru dan masukan terhadap taktik dan metode penangkapan ikan, melalui: analisis tahap proses pengoperasian dan analisis tingkah laku ikan di sekitar pencahayaan pada bagan petepete (boat lift net) yang menggunakan lampu LED. Penelitian ini dilaksanakan di perairan Kabupaten Barru-Selat Makassar, Sulawesi Selatan. Pengamatan lapang dilakukan dari bulan Juni sampai Agustus 2014 (20 trip). Analisis deskriptif dilakukan untuk melihat tahapan operasi penangkapan, sedangkan pengamatan tingkah laku ikan diamati dengan menggunakan fish finder. Tahapan pengoperasian bagan petepete adalah: persiapan operasi, menuju fishing ground, proses penyalaan lampu, proses penurunan waring (setting), proses menunggu kawanan ikan (soaking), proses pemadaman lampu, proses pengangkatan waring (hauling), pengambilan hasil tangkapan, dan proses pengangkatan waring ke atas bagan. Analisis tingkah laku ikan memperlihatkan pola pergerakan kawanan ikan mendatangi pencahayaan berada pada kedalaman 5-10 m dan 20-40 m dari segala arah pada saat semua lampu dinyalakan. Pola kawanan ikan terkonsentrasi di sekitar catchable are...

The effects of antioxidants, vitamins C and E, on sperm quality, testosterone levels, superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration were studied in artesunate treated rats. 25 male rats (160 to 250 g) divided into five groups were used for the study. Group 1 animals received normal saline and served as control while groups 2 to 5 received artesunate in therapeutic doses of 2.9 mg/Kg body weight on day 1 and 1.45 mg/Kg body weight on days 2 to 5 orally. Following artesunate pretreatment, groups 3, 4 and 5 rats received vitamin C (100 mg/kg), vitamin E (100 mg/kg) and a combination of both respectively orally for the 5 days. There was no significant difference in sperm viability and motility in all groups while count significantly (p<0.05) increased in group 3 animals treated with vitamin C. Serum testosterone level was significantly increased (p< 0.05) in groups 4 and 5. The MDA concentrations were significantly increased (p < 0.05) while SOD activity concurrently decreased significantly (p<0.05) in groups 2, 3, and 5 indicating an oxidative-counter oxidative relationship. It was thus concluded that artesunate at therapeutic doses and duration had no significant effect on sperm quality and serum testosterone level in male rats while vitamin C, and combination of vitamins C and E tend to promote reproductive functions in artesunate-treated male rats.