What are the novel findings of this work? Without cytomegalovirus (CMV) serology screening in pregnancy, routine detailed ultrasound examination identified 26% of infected fetuses that developed severe long-term sequelae, although non-specific infection-related findings had been reported in 64% of cases without raising suspicion. However, targeted ultrasound of known infected fetuses had a sensitivity of 91% and negative predictive value of 96% for detection of long-term sequelae. What are the clinical implications of this work? Routine detailed ultrasound examination in pregnancy is not an appropriate screening tool for congenital CMV infection that leads to long-term sequelae. Awareness of the sonologist regarding congenital CMV and knowledge of the maternal serological status in the first trimester are key to the diagnostic performance of prenatal ultrasound.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.