Background: Triple negative breast cancers (TNBC) are resistant to conventional therapies and molecular targets of TNBC are not explored in detail. Results: Coupling of ER stress and the MEK/ERK pathway by nifetepimine effectively kills TNBC cells. Conclusion: Nifetepimine plays a significant role in inducing apoptosis in TNBC cells. Significance: Our findings strongly suggest that nifetepimine may act as a potent anti-cancer agent for treatment of TNBC.

Background: Tumor-induced SERCA3 up-regulation is a major cause of death of CD4 ϩ T lymphocytes leading to immune

In this study, we report a highly stereoselective and versatile synthesis of spiro pyrazolones, promising motifs that are being employed as pharmacophores.

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