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Integrin-linked kinase (ILK) has been implicated as a molecular driver and mediator in both inflammation and tumorigenesis of the colon. ILK functions as an adaptor and mediator protein linking the extracellular matrix with downstream signaling pathways. ILK is broadly expressed in many human tissues and cells. It is also overexpressed in many cancers, including colorectal cancer (CRC). Inflammation, as evidenced by inflammatory bowel disease (IBD), is one of the highest risk factors for initiating CRC. This has led to the hypothesis that targeting ILK therapeutically could have potential in CRC, as it regulates different cellular processes associated with CRC development and progression as well as inflammation in the colon. A number of studies have indicated an ILK function in senescence, a cellular process that arrests the cell cycle while maintaining active metabolism and transcription. Senescent cells produce different secretions collectively known as the senescence-associated secretory phenotype (SASP). The SASP secretions influence infiltration of different immune cells, either positively for clearing senescent cells or negatively for promoting tumor growth, reflecting the dual role of senescence in cancer. However, a role for ILK in senescence and immunity in CRC remains to be determined. In this review, we discuss the possible role for ILK in senescence and immunity, paying particular attention to the relevance of ILK in CRC. We also examine how activating Toll-like receptors (TLRs) and their agonists in CRC could trigger immune responses against cancer, as a combination therapy with ILK inhibition.

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The power industry is in the process of grid modernization with the introduction of phasor measurement units (PMUs), advanced metering infrastructure (AMI), and other technologies. Although these technologies enable more reliable and efficient operation, the risk of cyber threats has increased, as evidenced by the recent blackouts in Ukraine and New York. One of these threats is false data injection attacks (FDIAs). Most of the FDIA literature focuses on the vulnerability of DC estimators and AC estimators to such attacks. This paper investigates FDIAs for PMU-based state estimation, where the PMUs are comparable. Several states can be manipulated by compromising one PMU through the channels of that PMU. A Phase Locking Value (PLV) technique was developed to detect FDIAs. The proposed approach is tested on the IEEE 14-bus and the IEEE 30-bus test systems under different scenarios using a Monte Carlo simulation where the PLV demonstrated an efficient performance.

Safety and critical applications employ fault-tolerant control systems (FTCS) to increase reliability and availability in the event of a failure of critical components. Process facilities may employ these technologies to cut down on production losses caused by equipment failures that occur on an irregular or unscheduled basis. Air–fuel ratio (AFR) adjustment in the fuel system of internal combustion engines (ICE) is crucial for enhancing engine efficiency, saving fuel energy, and safeguarding the environment. This paper proposes a novel hybrid fault-tolerant control system (HFTCS) for controlling the AFR in ICEs that combines the features of both an active fault-tolerant control system (AFTCS) and a passive fault-tolerant control system (PFTCS). The fault detection and isolation (FDI) unit is designed using fuzzy logic (FL) as part of an AFTCS to give estimated sensor values to the engine controller when the sensor becomes faulty. Super-twisting sliding mode control (ST-SMC) is implemented as part of a PFTCS to maintain AFR by adjusting the throttle actuator in the fuel supply line under faulty conditions. Lyapunov stability analysis is also performed to make sure that the system remains stable in both normal and faulty conditions. According to the results in the Matlab/Simulink environment, the suggested system stays robust and stable during sensor faults. In faulty situations, it also maintains the AFR at 14.6 without any degradation, and a comparison with previous studies is carried out. The study shows that the suggested approach is an innovative and highly dependable solution for AFR control in ICEs, preventing engine shutdown and output loss for higher profitability.