Topical treatment of skin and nail diseases is desirable in terms of patient acceptability and reduction of side effects associated with systemic drug delivery. This is particularly the case for nail diseases as they are frequently difficult to cure and also require long periods of treatment (Kassan et al., 1996). The nail plate is a highly keratinized tissue, which is characterized by low permeability to diffusing substance. The nail diseases are widely spread in the population, particularly among elderly and immune-compromised patients (Mohorcic et al., 2007). Current research on nail permeation focuses on altering the, nail plate barrier by means of chemical treatments and penetration
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.