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The present clinical series of Wolfram syndrome reveals a varied clinical presentation of the syndrome and some new associations.

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Cushing’s syndrome in pregnancy is a rare phenomenon and there is limited literature on its management. Cushing’s disease in pregnancy is even less common and there is little guidance to help in the treatment for this patient group. Diagnosis of Cushing’s syndrome in pregnancy is often delayed due to overlap of symptoms. In addition, there are no validated diagnostic tests or parameters documented. We present a case of a 30-year-old woman presenting to the antenatal clinic at 13 weeks of pregnancy with high suspicion of Cushing’s disease. Her 21-week fetal scan showed a congenital diaphragmatic hernia and she underwent pituitary magnetic resonance imaging, which confirm Cushing’s disease. She successfully underwent transsphenoidal adenomectomy with histology confirming a corticotroph adenoma. Tests following transsphenoidal surgery confirmed remission of Cushing’s disease and she underwent an emergency caesarean section at 38 weeks. Unfortunately, her baby died from complications associated with the congenital abnormality 36 hours after birth. The patient remains in remission following delivery. To date, there have been no reported cases of congenital diaphragmatic hernia associated with Cushing’s disease in pregnancy. In addition, we believe that this is only the eighth reported patient to have undergone successful transsphenoidal surgery for Cushing’s disease in pregnancy.

The RADARSAT Constellation is an evolution of the RADARSAT program with the objective of assuring C-band data continuity in the next decade with improved operational use of Synthetic Aperture Radar (SAR) and improved system reliability. This paper describes mission's main objectives and user requirements, as well as its concept and current status.