Objective: To evaluate post-traumatic growth experienced by medical doctors who served coronavirus disease-2019 patients. Method: The cross-sectional study was conducted from December 1, 2021, to February 28, 2022, at the Civil Hospital, Karachi, and comprised medical doctors of either gender aged >22 years who directly provided care for at least one month to coronavirus disease-2019 patients. Other than demographic and professional profile of the subjects, data was collected using the Post-Traumatic Growth Inventory, with total score 60 indicating a positive post-traumatic growth. Data was analysed using SPSS 22. Results: Of the 166 subjects approached, 150(90.3%) finished the study. There were 90(60%) females, 88(58.7%) were aged 25-35 years, 55(36.7%) were married, 107(71.3%) were postgraduate trainees, 79(52.7%) had 1-3 family members in the vulnerable groups, and 43(28.7%) had received any sort of psychological training. The mean post-traumatic growth score was 64.81±20.27 and 87(58%) doctors scored 60. The odds of experiencing post-traumatic growth for doctors with the number of vulnerable family members were significant (p 0.05). Doctors who had received psychological training before providing care to coronavirus disease-2019 patients showed higher odds of experiencing post-traumatic growth (p 0.05). Conclusion: Coronavirus disease-2019 resulted in substantial positive psychological growth for frontline doctors. Psychological training showed a significant role in post-traumatic growth. Key Words: Post-traumatic growth, Psychological COVID-19, Healthcare provider, Pakistan.
Objective: To determine the frequency of drug detoxification treatment completers and non-completers admitted at a tertiary care public hospital at Karachi. Study Design: Descriptive Cross Sectional study. Setting: Department of Psychiatry, Civil Hospital, Karachi. Period: 15thJanuary 2018 to 15thJune 2018. Material & Methods: Totals 124cases of substance users of any type who fulfilled the inclusion criteria were included in the study. History and thorough examinations carried out at ward. Results: Predominant age group was 26-35 years with majority of unemployed and brought for admission by family. Majority were using cannabinoids followed by opioids through smoking and snuffing form. Majority of them were admitted for first time and were taking substance for 1-5 years and every day. Out of 124 males 58.9% completed treatment while 41.1% did not complete treatment and left ward. Statistically age group, employment status, no of admissions, duration of use and frequency of use were significant. Conclusion: The study showed that there is a quite high and alarming ratio of patients who do not succeed to quite substance use.
Objectives: To observe the effect of lagenaria siceraria on inflammation and fibrosis brought about by arsenic in liver of Sprague Dawley rat. Study Design: Laboratory based randomized control trial. Place and Duration of Study: This experiment was performed at Department of Anatomy, Army Medical College Rawalpindi in co-operation with National Institute of Health (NIH) Islamabad for eight weeks (1st March 2017 to 25th April 2017). Material and Methods: Fifty Sprague Dawley rats (both male and females housed separately) were carefully chosen and distributed randomly into five groups, each consisting of 10 animals. A and B were the control groups whereas C, D and E served as experimental groups. During the first four weeks, experiment groups C, D and E were given a dosage of 5milligram/kilogram body weight of sodium arsenite. At the end of four weeks, animals from control group A and experimental group C were dissected and liver samples were processed for microscopic studies. In the next 4 weeks, group D animals were set aside without any further intervention. At that time, sodium arsenite at a dose of 5 milligram/kilogram body weight and lagenaria siceraria at a dose of 100 milligram/kilogram bodyweight were administered to group E animals. Group B animals served as control for experimental groups D and E. At the end of these 4 weeks animals of groups B, D and E were dissected. Liver was processed, fixed and stained for microscopic study. Area of portal triad as well as liver lobules were studied for inflammation and fibrosis and results were analysed. Statistical tool used to analyse the data was SPSS v 22. Results were considered to be significant when p-value is ≤ 0.05. Results: Experimental group C developed moderate grade fibrosis and inflammation (grade 2 to 3) as compared to group A. Degree of inflammation and fibrosis was mild to moderate (grade 1 to 2) in group D. There was no inflammation and fibrosis (Grade 0 to 1) in group E. Group B served as a control for group D and E. Conclusion: Inflammation and fibrosis developed in the liver of adult rats when they were subjected to sodium arsenite even for a brief calculated period. Simultaneous administration of lagenaria siceraria can shield and diminish the toxic effects of arsenic. Oxidative potential and immunomodulatory properties and presence of flavonoid like substances renders lagenaria siceraria to act as ameliorative against this fibrosis and inflammation in liver lobules and surrounding area of portal triads.
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